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非处方苯佐卡因导致的高铁血红蛋白血症

Methemoglobinemia secondary to over-the-counter Anbesol.

作者信息

Orr Timothy M, Orr Daniel L

机构信息

Stony Brook Medical Center, Stony Brook, New York, USA.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Feb;111(2):e7-e11. doi: 10.1016/j.tripleo.2010.06.011. Epub 2010 Oct 16.

Abstract

BACKGROUND

Methemoglobinemia is a potentially lethal condition which may result from exposure to benzocaine. It must be treated promptly, because it may cause a significant decrease in oxygen delivery to tissues and organs.

CASE DESCRIPTION

A 39-year-old caucasian man presented to the emergency department (ED) with dental pain. After a review of systems and a dental exam, an oxygen saturation of 90% was noted. The patient reported no previous cardiac or pulmonary pathology, but did report using a large amount of over-the-counter Anbesol. A second oxygen saturation measurement had fallen to 87%. An arterial blood gas sample was taken, and the patient was found to have high levels of methemoglobin. He was transferred to the critical care ED and treated with 2 mg/kg intravenous methylene blue.

CLINICAL IMPLICATIONS

Dentists must be aware of the possible lethal effects of benzocaine toxicity, including methemoglobinemia. It is important to recognize the signs and symptoms and act in a judicious manner.

摘要

背景

高铁血红蛋白血症是一种可能因接触苯佐卡因而导致的潜在致命病症。必须及时治疗,因为它可能会导致组织和器官的氧气输送显著减少。

病例描述

一名39岁的白人男性因牙痛前往急诊科就诊。在进行系统回顾和牙科检查后,发现其血氧饱和度为90%。患者报告既往无心脏或肺部疾病史,但确实报告使用了大量非处方的安必速(Anbesol)。再次测量血氧饱和度已降至87%。采集了动脉血气样本,发现该患者高铁血红蛋白水平较高。他被转至急诊科重症监护病房,并接受了2mg/kg静脉注射亚甲蓝治疗。

临床意义

牙医必须意识到苯佐卡因毒性(包括高铁血红蛋白血症)可能产生的致命影响。认识到其体征和症状并明智地采取行动非常重要。

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