Ludwig Maximilians University Munich, First Department of Obstetrics and Gynecology, Maistrasse 11, 80337 Munich, Germany.
In Vivo. 2010 Sep-Oct;24(5):695-8.
Inhibins and activins are important regulators of the female reproductive system. Recently, two novel inhibin subunits, named betaC (βC) and betaE (βE), have been identified. However, only limited data on the expression of the βC subunit in human endometrioid adenocarcinomas exist.
Samples of uterine endometrioid adenocarcinomas were obtained and analysed by immunohistochemistry for the immunolabelling with an inhibin-βC antibody. Additionally, the endometrial cancer cell line HEC-1a was used to assess the inhibin-betaC expression with the use of immunofluorescence.
Expression of the inhibin-βC subunit was demonstrated at the protein level by means of immunohistochemical evaluation in human endometrioid adenocarcinomas and the HEC-1a cell line.
This study demonstrated, for the first time, that the novel inhibin/activin-βC subunit is expressed in human endometrioid adenocarcinomas and in the human endometrial carcinoma cell line HEC-1a. Whether this novel β-subunit has a substantial role in the pathogenesis and malignant transformation in human endometrium is still under investigation.
抑制素和激活素是女性生殖系统的重要调节因子。最近，两种新的抑制素亚基，命名为βC（βC）和βE（βE），已经被鉴定出来。然而，关于βC 亚基在人子宫内膜样腺癌中的表达，仅有有限的数据。
收集子宫子宫内膜样腺癌样本，并用抑制素-βC 抗体进行免疫组织化学分析，以检测免疫标记。此外，使用免疫荧光法评估子宫内膜癌细胞系 HEC-1a 中的抑制素-βC 表达。
通过免疫组织化学评估，在人子宫内膜样腺癌和 HEC-1a 细胞系中，均证实了抑制素-βC 亚基在蛋白质水平上的表达。
本研究首次证明，新型抑制素/激活素-βC 亚基在人子宫内膜样腺癌和人子宫内膜癌细胞系 HEC-1a 中表达。该新型β-亚基在人子宫内膜的发病机制和恶性转化中是否具有重要作用，仍在研究中。
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