Military Medical Research and Integrative Medicine, Samueli Institute, 2101 East Coast Hwy, Corona Del Mar, CA 92625, USA.
Evid Based Complement Alternat Med. 2011;2011. doi: 10.1155/2011/636134. Epub 2010 Sep 8.
A systematic review was conducted to assess the level of evidence for integrative health care research. We searched PubMed, Allied and Complementary Medicine (AMED), BIOSIS Previews, EMBASE, the entire Cochrane Library, MANTIS, Social SciSearch, SciSearch Cited Ref Sci, PsychInfo, CINAHL, and NCCAM grantee publications listings, from database inception to May 2009, as well as searches of the "gray literature." Available studies published in English language were included. Three independent reviewers rated each article and assessed the methodological quality of studies using the Scottish Intercollegiate Guidelines Network (SIGN 50). Our search yielded 11,891 total citations but 6 clinical studies, including 4 randomized, met our inclusion criteria. There are no available systematic reviews/meta-analyses published that met our inclusion criteria. The methodological quality of the included studies was assessed independently using quality checklists of the SIGN 50. Only a small number of RCTs and CCTs with a limited number of patients and lack of adequate control groups assessing integrative health care research are available. These studies provide limited evidence of effective integrative health care on some modalities. However, integrative health care regimen appears to be generally safe.
系统评价评估整合医疗保健研究的证据水平。我们检索了 PubMed、辅助和补充医学（AMED）、BIOSIS Previews、EMBASE、整个 Cochrane 图书馆、MANTIS、社会科学搜索、SciSearch 引用参考科学、心理信息、CINAHL 和 NCCAM 资助者出版物清单，从数据库建立到 2009 年 5 月，以及对“灰色文献”的搜索。纳入了发表在英文的研究。三名独立评审员对每篇文章进行评分，并使用苏格兰校际指南网络（SIGN 50）评估研究的方法学质量。我们的搜索共产生了 11891 条总引用，但只有 6 项临床研究，包括 4 项随机对照试验，符合我们的纳入标准。没有符合我们纳入标准的已发表的系统评价/荟萃分析。使用 SIGN 50 的质量检查表独立评估纳入研究的方法学质量。只有少数 RCT 和 CCT 提供了一些评估整合医疗保健研究的模式，这些研究提供了有限的有效整合医疗保健的证据。然而，整合医疗保健方案似乎通常是安全的。
