Eichler I, Burghuber O C, Götz M
Department of Pediatrics, University of Vienna, Austria.
Eur J Clin Pharmacol. 1990;39(6):587-8. doi: 10.1007/BF00316101.
Hypoxic pulmonary vasoconstriction is considered to be the primary cause of pulmonary hypertension and cor pulmonale in adult patients with cystic fibrosis (CF). The acute effect on pulmonary haemodynamics of a single sublingual dose of nifedipine 20 mg has been studied in 9 adult patients with CF. Nifedipine significantly attenuated the rise in mean pulmonary artery pressure and pulmonary vascular resistance induced by inhalation of a 13% oxygen gas mix. It also slightly reduced baseline pulmonary artery pressure and pulmonary vascular resistance and lowered pulmonary artery hypertension in the patients. Oxygen delivery was unchanged. Nifedipine is potentially useful for the treatment of hypoxic pulmonary hypertension in patients with CF.
低氧性肺血管收缩被认为是成年囊性纤维化（CF）患者发生肺动脉高压和肺心病的主要原因。对9例成年CF患者研究了单次舌下含服20毫克硝苯地平对肺血流动力学的急性影响。硝苯地平显著减轻了吸入13%氧气混合气引起的平均肺动脉压和肺血管阻力的升高。它还略微降低了患者的基线肺动脉压和肺血管阻力，并降低了肺动脉高压。氧输送未发生变化。硝苯地平可能对CF患者低氧性肺动脉高压的治疗有用。
