钯（II）/铜（I）-协同催化 2-（1-炔基）-2-烯-1-酮、亲核试剂和二芳基碘鎓盐的三组分串联反应合成四取代呋喃。
Tetrasubstituted furans by Pd(II)/Cu(I)-cocatalyzed three-component domino reactions of 2-(1-alkynyl)-2-alken-1-ones, nucleophiles and diaryliodonium salts.
机构信息
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, PR China.
出版信息
Chem Commun (Camb). 2010 Dec 14;46(46):8839-41. doi: 10.1039/c0cc03450a. Epub 2010 Oct 18.
PMID:20953496
Abstract
A novel Pd(OAc)(2)/CuI-cocatalyzed three-component reaction of 2-(1-alkynyl)-2-alken-1-ones, nucleophiles and diaryliodonium salts has been developed. The procedure allows the synthesis of tetrasubstituted furans in good to high yields under mild conditions.
摘要
一种新型的 Pd(OAc)(2)/CuI 共催化的 2-(1-炔基)-2-烯-1-酮、亲核试剂和二芳基碘鎓盐的三组分反应已经被开发出来。该方法在温和条件下能够以良好到较高的收率合成四取代呋喃。
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