Barth D, Harth W, Treudler R, Simon J C
Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig A.ö.R., Leipzig.
Hautarzt. 2011 Jun;62(6):459-62. doi: 10.1007/s00105-010-2058-9.
Necrobiosis lipoidica (NL) is a chronic inflammatory skin disease that is difficult to treat. The etiology is unknown, but vascular abnormalities and immunologic factors have been implicated. We treated a patient with long-standing NL with multiple vascular risk factors (diabetes mellitus, protein S-deficiency, and antiphospholipid syndrome) with topical tacrolimus, a non-steroidal immunomodulator that causes no skin atrophy. After 12 weeks of topical tacrolimus (0.1%) ointment, our patient already showed a good remission with a significant decrease in inflammatory signs.
类脂质渐进性坏死（NL）是一种难以治疗的慢性炎症性皮肤病。其病因不明，但与血管异常和免疫因素有关。我们用外用他克莫司治疗了一名患有多种血管危险因素（糖尿病、蛋白S缺乏症和抗磷脂综合征）的长期NL患者，他克莫司是一种不会引起皮肤萎缩的非甾体免疫调节剂。外用他克莫司（0.1%）软膏治疗12周后，我们的患者已显示出良好的缓解，炎症体征显著减轻。
