School of Paediatrics and Child Health, University of Western Australia, c/- Princess Margaret Hospital for Children, Perth, Australia.
Indian J Pediatr. 2010 Oct;77(10):1173-81. doi: 10.1007/s12098-010-0206-y. Epub 2010 Oct 16.
Fevers in children are mainly due to infection, malignancy or inflammatory conditions. Rheumatologists have an important role in the care of inflammatory conditions, many of which are associated with fevers. Seven conditions, the hereditary recurrent fever syndromes, have been defined with the presenting symptom of recurring fever, and for which mutation of a single gene has been defined: Chronic infantile neurological articular syndrome (CINCA), Familial cold autoinflammatory syndrome (FACS), Familial Mediterranean fever (FMF), hyperimmunoglobulinemia D (HIDS), Muckle-Wells syndrome (MWS), Pyogenic sterile arthritis and Pyoderma gangrenosum (PAPA) and Tumour necrosis factor receptor-associated periodic syndrome (TRAPS) . These conditions will be discussed in detail in regard to how they fit into the wider picture of pediatric rheumatological conditions, how the diagnoses may be established and the current recommended treatments for each condition.
儿童发热主要由感染、恶性肿瘤或炎症性疾病引起。风湿科医生在炎症性疾病的治疗中发挥着重要作用，其中许多疾病都与发热有关。七种遗传性复发性发热综合征的特征是反复发热，且已明确其与单个基因突变相关：慢性婴儿神经关节皮肤综合征（CINCA）、家族性冷自身炎症综合征（FCAS）、家族性地中海热（FMF）、高免疫球蛋白 D 血症（HIDS）、穆勒-韦尔斯综合征（MWS）、化脓性关节炎和坏疽性脓皮病（PAPA）和肿瘤坏死因子受体相关周期性综合征（TRAPS）。本文将详细讨论这些疾病在儿科风湿性疾病中的广泛表现、诊断方法以及每种疾病的推荐治疗方案。
