[The distribution of insulin-containing cells in the developing tissues of the common frog (Rana temporaria)].

Monoclonal antibodies to pig insulin were used to follow the changes in localization of insulin-containing cells during the ontogenesis of the brown frog, Rana temporaria L., from stage 20 (Dabagian, Sleptsova, 1975) until completion of metamorphosis and beginning of active nutrition. Insulin-containing were localized in brain, surface epithelium, intestine, olfactory epithelium, taste teats, kidney tubules, ciliated epithelium of the oral cavity, pancreas, Jacobson and interjaw glands was found out. Localization of insulin-containing cells and type of their specific fluorescence varied at different stages of development. Formation of the insulin-containing system of amphibians on the whole is typical for the development of diffuse endocrine system in vertebrates.