Department of Neurology & Rehabilitation, University of Illinois College of Medicine at Chicago, Chicago, Illinois, USA.
Ann N Y Acad Sci. 2010 Oct;1207:155-62. doi: 10.1111/j.1749-6632.2010.05726.x.
Inflammation may be an important mechanism underlying dementia and cognitive decline in the elderly. Inflammation has been implicated in the neuropathological cascade leading to the development of Alzheimer's disease and other common forms of dementia in later life. These observations have led to observational epidemiological study to define the association of systemic and brain inflammatory markers on cognitive impairment and dementia. Furthermore, clinical trials have been carried out to better elucidate the possible role of nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention or slowing of progression of Alzheimer's disease. In this review, we discuss the observational epidemiological and clinical trial evidence of the role of inflammation on the occurrence and prevention of dementia or cognitive decline. NSAIDs hold promise to prevent dementia if given in an appropriate time window during the induction phase of dementia and to subjects with apolipoprotein E (APOE) e4 alleles. Also, immunotherapy may prove beneficial.
炎症可能是老年人痴呆和认知能力下降的重要机制。炎症与导致阿尔茨海默病和其他常见形式的痴呆的神经病理学级联反应有关。这些观察结果导致了观察性流行病学研究，以确定全身和大脑炎症标志物与认知障碍和痴呆的关联。此外，还进行了临床试验，以更好地阐明非甾体抗炎药 (NSAIDs) 在预防或减缓阿尔茨海默病进展中的可能作用。在这篇综述中，我们讨论了炎症在痴呆发生和预防中的作用的观察性流行病学和临床试验证据。如果在痴呆诱导期内，在适当的时间窗口内给予 NSAIDs，并给予载脂蛋白 E (APOE) e4 等位基因的受试者，它们有可能预防痴呆。此外，免疫疗法可能也会有帮助。
