Department of Psychology, University of Turin, Turin, Italy.
Neurosciences Department "Rita Levi Montalcini", University of Turin, Turin, Italy.
Adv Exp Med Biol. 2024;1457:143-164. doi: 10.1007/978-3-031-61939-7_8.
In the face of increasing reports of CNS involvement in COVID-19 cases, it is likely that the current epidemic may be accompanied by a significant increase in the prevalence of neurological sequelae, cognitive dysfunction, and long-term behavioural alterations affecting quality of life and autonomy in daily life. This is consequential to the neuroinvasion and multi-organ dysfunction, but also to the psychological distress and socioeconomic changes that occur. Long COVID and neurocovid are now an established concept worldwide. However, the clinical features of these two entities are still debated. The chapter provides information about the nosographic framing, associated pathophysiological mechanisms, alterations in the central and peripheral nervous systems, and the associated neurocognitive profile, indications about predictor and clinical evaluation according to a patient-centred multidimensional immuno-behavioural approach.
面对越来越多的关于 COVID-19 病例中枢神经系统受累的报告，目前的疫情可能伴随着神经后遗症、认知功能障碍和长期行为改变的患病率显著增加，这些都会影响生活质量和日常生活的自主性。这是由于神经入侵和多器官功能障碍，也是由于发生的心理困扰和社会经济变化。长 COVID 和神经 COVID 现在是全球公认的概念。然而，这两个实体的临床特征仍存在争议。本章提供了关于分类框架、相关病理生理机制、中枢和外周神经系统改变以及相关神经认知特征的信息，根据以患者为中心的多维免疫行为方法，提供了关于预测因子和临床评估的信息。
