Department of Microbiology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
APMIS. 2010 Nov;118(11):895-902. doi: 10.1111/j.1600-0463.2010.02676.x. Epub 2010 Sep 2.
Avian influenza virus H5N1 infects and causes severe disease in humans. Despite the increasing number of fatal cases in 15 countries and the threat of influenza pandemic, detailed pathologic and virologic findings in humans are limited. In this study, we describe histopathologic findings, distributions of viral RNA and the Neu5Acα2-3Galβ1-4 sialic acid receptor in human tissues from three fatal avian influenza cases. Many of our findings are in agreement with previously published autopsy studies, that is, viral RNA and receptor were detected in type II pneumocytes, tracheal epithelium, intestinal epithelium, spleen, lymph nodes, and Kupffer's cells. In addition, we detected the viral RNA in glomeruli and renal tubules. There was a good correlation between viral RNA distribution and the presence of the sialic acid receptor. Despite the wide distribution of viral RNA, tissue damage and inflammation were mainly limited to pulmonary tissue.
禽流感病毒 H5N1 可感染人类并导致严重疾病。尽管在 15 个国家中致命病例的数量不断增加，且存在流感大流行的威胁，但人类中详细的病理和病毒学发现仍很有限。在这项研究中，我们描述了三例致命禽流感病例的人组织中的组织病理学发现、病毒 RNA 分布和 Neu5Acα2-3Galβ1-4 唾液酸受体。我们的许多发现与以前发表的尸检研究一致，即病毒 RNA 和受体存在于 II 型肺泡细胞、气管上皮、肠上皮、脾脏、淋巴结和枯否氏细胞中。此外，我们还在肾小球和肾小管中检测到了病毒 RNA。病毒 RNA 分布与唾液酸受体的存在之间存在良好的相关性。尽管病毒 RNA 广泛分布，但组织损伤和炎症主要局限于肺部组织。
