Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Vaccine. 2010 Nov 29;28(51):8095-104. doi: 10.1016/j.vaccine.2010.10.003. Epub 2010 Oct 16.
We recently reported an attenuated EIAV vaccine study that directly examined the effect of lentiviral envelope sequence variation on vaccine efficacy. The study [1] demonstrated for the first time the failure of an ancestral vaccine to protect and revealed a significant, inverse, linear relationship between envelope divergence and protection from disease. In the current study we examine in detail the evolution of the attenuated vaccine strain utilized in this previous study. We demonstrate here that the attenuated strain progressively evolved during the six-month pre-challenge period and that the observed protection from disease was significantly associated with divergence from the original vaccine strain.
我们最近报道了一项减弱的 EIAV 疫苗研究，该研究直接考察了慢病毒包膜序列变异对疫苗效力的影响。该研究[1]首次证明了祖先疫苗无法保护，并揭示了包膜分歧与疾病保护之间存在显著的、线性的反比关系。在本研究中，我们详细研究了之前研究中使用的减弱疫苗株的进化情况。我们在此证明，在六个月的攻毒前期间，减弱的毒株逐渐进化，并且观察到的疾病保护与与原始疫苗株的分歧显著相关。
