Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA.
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19044-8. doi: 10.1073/pnas.1014391107. Epub 2010 Oct 18.
It has been proposed that a core network of brain regions, including the hippocampus, supports both past remembering and future imagining. We investigated the importance of the hippocampus for these functions. Five patients with bilateral hippocampal damage and one patient with large medial temporal lobe lesions were tested for their ability to recount autobiographical episodes from the remote past, the recent past, and to imagine plausible episodes in the near future. The patients with hippocampal damage had intact remote autobiographical memory, modestly impaired recent memory, and an intact ability to imagine the future. The patient with large medial temporal lobe lesions had intact remote memory, markedly impaired recent memory, and also had an intact ability to imagine the future. The findings suggest that the capacity for imagining the future, like the capacity for remembering the remote past, is independent of the hippocampus.
有人提出，包括海马体在内的大脑区域核心网络支持过去的记忆和未来的想象。我们研究了海马体对这些功能的重要性。我们测试了 5 名双侧海马体损伤患者和 1 名内侧颞叶大损伤患者回忆遥远过去、近期过去的自传体事件以及想象近期未来可能发生的事件的能力。海马体损伤患者的遥远自传体记忆完好，近期记忆中度受损，对未来的想象能力完好。内侧颞叶大损伤患者的遥远记忆完好，近期记忆明显受损，对未来的想象能力也完好。这些发现表明，未来想象的能力，就像遥远过去记忆的能力一样，不依赖于海马体。
