Essex Neurosciences Centre, Queen's Hospital, Romford, Essex, UK.
Cortex. 2011 Apr;47(4):451-9. doi: 10.1016/j.cortex.2010.01.009. Epub 2010 Feb 17.
We describe the case of a patient with confirmed voltage-gated potassium channel antibody-associated encephalitis (VGKC-Ab). MRI studies revealed bilateral hyper-intensity in the hippocampi, with their volumes preserved. At presentation, the patient's anterograde and retrograde memory skills were found to be impaired and he showed fluctuation in his ability to recall familiar information. Following treatment with immunotherapy, his condition improved considerably and, in a series of follow up assessments, he performed satisfactorily (i.e., within the average range or above) on formal tests of memory, as well as on a range of other cognitive tests, including tests of executive function. By contrast, in the context of contemporaneous unstructured interviews, he showed a strong tendency to confabulate. We argue that the reported case broadens the phenomenology of VGKC-Ab limbic encephalitis and raises important theoretical questions about the aetiology of this patient's most unusual memory disorder.
我们描述了一例电压门控钾通道抗体相关脑炎（VGKC-Ab）患者的病例。MRI 研究显示双侧海马呈高信号，体积保持不变。就诊时，患者的顺行性和逆行性记忆技能受损，他表现出回忆熟悉信息能力的波动。经过免疫治疗后，他的病情明显改善，在一系列随访评估中，他在记忆等正式测试中表现出色（即处于平均水平或以上），以及一系列其他认知测试，包括执行功能测试。相比之下，在同时进行的非结构化访谈中，他表现出强烈的虚构倾向。我们认为，所报告的病例拓宽了 VGKC-Ab 边缘性脑炎的表现，并提出了关于该患者最不寻常记忆障碍病因的重要理论问题。
