Hye M A, Masud K M, Banik D, Banik D, Haque M F, Akhtaruzzaman K M
Department of Anaesthesia, Intensive Care and Pain Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka, Bangladesh.
Mymensingh Med J. 2010 Oct;19(4):586-93.
This study was done for intrathecal adjuncts often are used to enhance small dose spinal bupivacaine anaesthesia. We designed this study to evaluate the postoperative analgesic efficacy and safety of intrathecal neostigmine. A randomized, double-blind prospective study was conducted in 90 healthy term pregnant patients scheduled to undergoing elective caesarean section using spinal anaesthesia. Women were administered 12.5 mg bupivacaine alone or with 75 microgram and 150 microgram of neostigmine as intrathecal drug. Parametric data were analyzed using ANOVA. Chi-square test was used to analyze the incidence data. Neostigmine significantly increased the duration sensory and motor block (p<0.05) and the time until for achieving discharge criteria. The addition of neostigmine produced dose-dependent nausea and vomiting and had no significant effect on haemodynamic or respiratory parameters. Addition of neostigmine to intrathecal bupivacaine extends the duration of postoperative analgesia with fewer side-effects without adverse effects on fetus following caesarean section.
本研究旨在探讨鞘内辅助用药常被用于增强小剂量布比卡因脊髓麻醉的效果。我们设计本研究以评估鞘内注射新斯的明的术后镇痛效果及安全性。对90例计划行择期剖宫产脊髓麻醉的足月健康孕妇进行了一项随机、双盲前瞻性研究。将女性患者鞘内注射12.5mg布比卡因单独用药，或与75微克及150微克新斯的明联合用药。参数数据采用方差分析进行分析。卡方检验用于分析发病率数据。新斯的明显著延长了感觉和运动阻滞时间（p<0.05）以及达到出院标准的时间。添加新斯的明会产生剂量依赖性恶心和呕吐，对血流动力学或呼吸参数无显著影响。剖宫产术后鞘内布比卡因添加新斯的明可延长术后镇痛时间，副作用更少，且对胎儿无不良影响。
