Palka G, Spadano A, Calabrese G, Parruti G, Guanciali Franchi P, Di Sante O, Recchia A, Di Lorenzo R, Torlontano G
Istituto di Biologia e Genetica, Università di Chieti, Pescara, Italy.
Ann Genet. 1990;33(4):214-8.
The authors report on a cytogenetic survey of 61 patients with preleukemic syndrome (PLS). Of these, 41 had a myeloproliferative disease (MPD) and 20 a myelodysplastic syndrome (MDS). Clonal chromosome abnormalities appeared in 24 patients (39.3%) at disease onset. Such changes had a frequency of 26.8% in patients with MPD and 65% in those with MDS. The authors stress the usefulness of ethidium bromide high resolution techniques. They allow obtaining a larger number of metaphases and elongated chromosomes with higher banding resolution and could account for the frequent detection of chromosome changes in most groups of MDS patients in the present series. Moreover, they discuss the possible significance of some chromosome aberrations suggesting that patients with MPD may live longer than those with MDS because of their higher frequency of normal karyotypes.
作者报告了对61例白血病前期综合征（PLS）患者的细胞遗传学调查。其中，41例患有骨髓增殖性疾病（MPD），20例患有骨髓增生异常综合征（MDS）。24例患者（39.3%）在疾病发作时出现克隆性染色体异常。这种变化在MPD患者中的发生率为26.8%，在MDS患者中为65%。作者强调了溴化乙锭高分辨率技术的实用性。它们能够获得更多数量的中期分裂相和更长的染色体，具有更高的带型分辨率，这可以解释本系列中大多数MDS患者组中染色体变化的频繁检测。此外，他们讨论了一些染色体畸变的可能意义，表明MPD患者可能比MDS患者寿命更长，因为他们正常核型的频率更高。
