克霉唑与某些阴离子表面活性剂的协同作用可能归因于离子对的形成。
Synergistic action of clotrimazole and certain anionic surfactants may be due to ion pair formation.
作者信息
Pedersen M
机构信息
Department of Pharmaceutics, Royal Danish School of Pharmacy, Copenhagen, Denmark.
出版信息
Acta Pharm Nord. 1990;2(6):367-70.
PMID:2095795
Abstract
A synergistic effect of clotrimazole and certain anionic surfactants against a strain of Candida albicans was confirmed. Measurement of apparent partition coefficients indicated that lipophilic ion pairs between clotrimazole and anionic surfactants were formed. It is suggested that the synergistic effect of the drugs may be due to ion pair formation.
摘要
已证实克霉唑与某些阴离子表面活性剂对白色念珠菌菌株具有协同作用。表观分配系数的测定表明，克霉唑与阴离子表面活性剂之间形成了亲脂性离子对。提示药物的协同作用可能归因于离子对的形成。
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