Chernyĭ A P, Kosterin S A
Biofizika. 1990 Nov-Dec;35(6):972-6.
A model is proposed for Ca2+ stationary exchange in the myometrium cells in the absence of effects activating calcium channels of the plasmic membrane. The results of the model analysis point to an important role of the calcium pump (but not on Na(+)-Ca2+ exchanger) of the sarcolemma in providing the long-term regulation of physiologically significant concentration of ionized calcium in the smooth muscle cells. Ability of the calcium pump to efficiently compensate Ca2+ basal current continuously entering the myocytes at rest is proved. It is suggested that the stationary transsarcolemmal exchange of calcium (the system "basal calcium current--ATP-dependent transfer of Ca2+") underlies the control mechanism of the myometrium basal tonus, while a disturbance of the stationary state (with the pump inhibition) provides activation of the smooth muscle tonic contraction.
提出了一个在不存在激活质膜钙通道作用的情况下，子宫肌层细胞中钙离子稳态交换的模型。该模型分析结果表明，肌膜钙泵（而非钠钙交换体）在维持平滑肌细胞中具有生理意义的游离钙浓度的长期调节中起着重要作用。证明了钙泵能够有效补偿静息时持续进入肌细胞的钙离子基础电流。有人提出，钙离子的稳态跨肌膜交换（“基础钙电流 - 依赖ATP的钙离子转运”系统）是子宫肌层基础张力控制机制的基础，而稳态的破坏（伴随泵的抑制）会引发平滑肌强直性收缩。
