Iliceto S, Caiati C, Piccinni G, Tota F, De Martino G, Marangelli V, Rizzon P
Division of Cardiology, University of Bari, Italy.
Cardiologia. 1990 Dec;35(12):1023-6.
Transesophageal atrial pacing (TAP) 2D echocardiography was performed after placebo (P) and gallopamil (G) (0.03 mg/kg iv) in 12 patients with stable, reproducible, effort angina. If compared to P study, during G the following changes were observed: 3 out of the 12 patients did not experience angina, time to ST-1mm increased from 5.3 +/- 1.3 to 6.6 +/- 1.6 min (p less than 0.05), wall motion score was improved both at 130 b/min (15.3 +/- 4.1 drug P, 17 +/- 4.8 drug G, p less than 0.01) and at 150 b/min (10.9 +/- 5.7 drug P, 12.8 +/- 6.3 drug G, p = 0.07). In conclusion, gallopamil has a beneficial effect on atrial pacing induced ischemia: it increases pacing time to ischemic threshold and reduces during ischemia the extent of dysfunctional myocardium.
对12例稳定型、可重复性劳力性心绞痛患者，在给予安慰剂（P）和加洛帕米（G）（静脉注射0.03mg/kg）后，进行经食管心房起搏（TAP）二维超声心动图检查。与P组研究相比，在G组观察到以下变化：12例患者中有3例未发生心绞痛，ST段压低1mm的时间从5.3±1.3分钟增加到6.6±1.6分钟（p<0.05），在心率130次/分钟时（药物P组15.3±4.1，药物G组17±4.8，p<0.01）和150次/分钟时（药物P组10.9±5.7，药物G组12.8±6.3，p = 0.07）壁运动评分均得到改善。总之，加洛帕米对心房起搏诱发的缺血有有益作用：它增加起搏至缺血阈值的时间，并在缺血期间减少功能失调心肌的范围。
