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[分子标志物在尿路上皮癌诊断与治疗中的应用]

[Molecular markers in the diagnostics and therapy of urothelial cancer].

作者信息

Protzel C, Hakenberg O W

机构信息

Klinik und Poliklinik für Urologie, Urologische Univ.-Klinik Rostock, Ernst-Heydemann-Str. 6, 18057 Rostock, Deutschland.

出版信息

Urologe A. 2010 Nov;49(11):1415-24. doi: 10.1007/s00120-010-2431-4.

DOI:10.1007/s00120-010-2431-4
PMID:20959953
Abstract

Many clinical decisions in the management of bladder cancer would benefit from better and reliable knowledge of individual prognosis. Marker for urothelial cancer can principally be measured in blood, urine and transurethrally resected tissue. In recent years new markers have been identified by new technologies and this opens exiting avenues. Since no single marker gives a clear Yes-or-no prognostic answer but always only a measure of probability, the use of marker systems has so far not gained widespread clinical applications. This will likely change in future.

摘要

膀胱癌管理中的许多临床决策将受益于对个体预后更准确可靠的了解。尿路上皮癌标志物主要可在血液、尿液和经尿道切除的组织中检测。近年来,新技术鉴定出了新的标志物,这开辟了令人兴奋的途径。由于没有单一标志物能给出明确的预后肯定或否定答案,而始终只是一种概率衡量,因此标志物系统的应用迄今尚未在临床广泛开展。这种情况未来可能会改变。

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引用本文的文献

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Urologe A. 2013 Sep;52(9):1207-24. doi: 10.1007/s00120-013-3301-7.
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[Expression of the tumormarker p16INK4a in cytology specimens of the urinary bladder. A new means for early recognition and surveillance of urothelial cancer].[膀胱细胞学标本中肿瘤标志物p16INK4a的表达。一种早期识别和监测尿路上皮癌的新方法]
Urologe A. 2011 Sep;50(9):1130-3. doi: 10.1007/s00120-011-2693-5.
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[Use of marker systems in the treatment of bladder cancer].

本文引用的文献

1
Prognostic significance of survivin-expressing circulating tumour cells in T1G3 bladder cancer.T1G3 膀胱癌中存活素表达循环肿瘤细胞的预后意义。
BJU Int. 2010 Sep;106(5):710-5. doi: 10.1111/j.1464-410X.2009.09130.x.
2
Study of the prediction system for clinical response to M-VAC neoadjuvant chemotherapy for bladder cancer.膀胱癌M-VAC新辅助化疗临床反应预测系统的研究
Aktuelle Urol. 2010 Jan;41 Suppl 1:S41-5. doi: 10.1055/s-0029-1224655. Epub 2010 Jan 21.
3
The application of artificial intelligence to microarray data: identification of a novel gene signature to identify bladder cancer progression.
[标记系统在膀胱癌治疗中的应用]
Urologe A. 2011 Mar;50(3):303-8. doi: 10.1007/s00120-010-2412-7.
人工智能在微阵列数据中的应用:鉴定一种新的基因特征以识别膀胱癌的进展。
Eur Urol. 2010 Mar;57(3):398-406. doi: 10.1016/j.eururo.2009.10.029. Epub 2009 Nov 6.
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Concordant gene expression signatures predict clinical outcomes of cancer patients undergoing systemic therapy.一致性基因表达特征可预测接受全身治疗的癌症患者的临床结局。
Cancer Res. 2009 Nov 1;69(21):8302-9. doi: 10.1158/0008-5472.CAN-09-0798. Epub 2009 Oct 20.
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Emerging apoptosis agonists for bladder cancer.膀胱癌的新兴凋亡诱导剂。
Expert Opin Emerg Drugs. 2009 Dec;14(4):607-18. doi: 10.1517/14728210903251708.
6
Clusterin as a diagnostic and prognostic marker for transitional cell carcinoma of the bladder.簇集蛋白作为膀胱移行细胞癌的诊断和预后标志物。
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7
Utility of diagnostic and prognostic markers in urothelial carcinoma of the bladder.诊断和预后标志物在膀胱尿路上皮癌中的应用
Adv Anat Pathol. 2009 Mar;16(2):67-78. doi: 10.1097/PAP.0b013e318199f89e.
8
DNA microarray expression profiling of bladder cancer allows identification of noninvasive diagnostic markers.膀胱癌的DNA微阵列表达谱分析有助于识别非侵入性诊断标志物。
J Urol. 2009 Aug;182(2):741-8. doi: 10.1016/j.juro.2009.03.084. Epub 2009 Jun 18.
9
Bladder cancer screening in a high risk asymptomatic population using a point of care urine based protein tumor marker.使用即时检测尿液蛋白肿瘤标志物对高危无症状人群进行膀胱癌筛查。
J Urol. 2009 Jul;182(1):52-7; discussion 58. doi: 10.1016/j.juro.2009.02.142. Epub 2009 May 17.
10
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