Krotscheck Ursula, Boothe Dawn Merton, Little Amy A, Erb Hollis N
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, NY, USA.
Vet Ther. 2010 Fall;11(3):E1-8.
Alternatives to intravenous administration of opioids are needed in veterinary medicine. Previous research suggests that opioids can be administered through the buccal mucosa in dogs. This study reports the pharmacokinetics of buprenorphine HCl (0.05 mg/kg) administered transmucosally in six dogs compared with those of buprenorphine HCl (0.015 mg/kg) administered intravenously. The results suggest that the pharmacokinetics of buprenorphine HCl administered intravenously or transmucosally are similar and that transmucosal administration may be considered as a noninvasive alternative to intravenous administration.
兽医学需要阿片类药物静脉给药的替代方法。先前的研究表明，阿片类药物可通过犬的颊黏膜给药。本研究报告了6只犬经黏膜给予盐酸丁丙诺啡（0.05mg/kg）与静脉给予盐酸丁丙诺啡（0.015mg/kg）的药代动力学。结果表明，静脉给药或经黏膜给药的盐酸丁丙诺啡药代动力学相似，经黏膜给药可被视为静脉给药的一种非侵入性替代方法。
