运动可提高帕金森病小鼠模型中的多巴胺 D2 受体：[¹⁸F]氟比洛芬的体内成像。
Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: in vivo imaging with [¹⁸F]fallypride.
机构信息
Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA.
出版信息
Mov Disord. 2010 Dec 15;25(16):2777-84. doi: 10.1002/mds.23407.
Abstract
The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA-D2R specific ligand [¹⁸F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [¹⁸F]fallypride to examine DA-D2R changes in individuals with Parkinson's Disease (PD) undergoing high-intensity treadmill training.
摘要
本研究的目的是检测接受强化跑步机运动的 MPTP 小鼠基底神经节中多巴胺 D2 受体 (DA-D2R) 表达的变化。通过突触小体的 Western 免疫印迹分析和使用 DA-D2R 特异性配体 [¹⁸F]fallypride 的体内正电子发射断层扫描 (PET) 成像，我们发现高强度跑步机运动导致纹状体 DA-D2R 表达增加，与生理盐水处理的小鼠相比，MPTP 处理的小鼠更为明显。多巴胺耗竭基底神经节中 DA-D2R 的运动诱导变化与该受体在调节中脑多巴胺能神经元 (MSNs) 功能和行为恢复中的潜在作用一致。重要的是，这项研究的结果支持使用 [¹⁸F]fallypride 的 PET 成像来检查接受高强度跑步机训练的帕金森病 (PD) 个体中 DA-D2R 变化的原理。
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Neurobiol Dis. 2009 Sep;35(3):376-84. doi: 10.1016/j.nbd.2009.05.019. Epub 2009 Jun 6.
3
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4
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Mov Disord. 2008;23 Suppl 3:S534-47. doi: 10.1002/mds.22027.
5
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Synapse. 2008 Jun;62(6):399-408. doi: 10.1002/syn.20506.
6
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7
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