Meerman R J, van Bel F, van Zwieten P H, Oepkes D, den Ouden L
Department of Obstetrics and Gynecology, University Hospital, Leiden, The Netherlands.
Early Hum Dev. 1990 Dec;24(3):209-17. doi: 10.1016/0378-3782(90)90028-h.
In a longitudinal Doppler ultrasound study fetal and early neonatal cerebral blood flow velocities were assessed in the middle cerebral artery in 40 uncomplicated pregnancies during the third trimester of pregnancy and in 22 neonates born from these pregnancies. Peak systolic (PSFV), temporal mean (TMFV), and end diastolic flow velocities (EDFV) were determined and pulsatility index (PI = (PSFV - EDFV)/TMFV) and Pourcelot's resistance index (RI = (PSFV - EDFV)/PSFV) calculated. PSFV, TMFV and EDFV increased during the third trimester of pregnancy and were significantly higher from 36 weeks of gestation onward as compared to values obtained at 28 weeks of gestation, suggesting an increase in actual cerebral blood flow. PI and RI of the MCA did not differ significantly during this period. Immediately after birth PSFV, TMFV and EDFV decreased significantly and remained lower during the first 5 postnatal days compared to fetal values. PI and RI of the MCA tended to decrease during the first postnatal day, but stabilized afterwards.
在一项纵向多普勒超声研究中，对40例孕晚期无并发症妊娠的胎儿及22例由这些妊娠分娩的新生儿的大脑中动脉的血流速度进行了评估。测定了收缩期峰值流速（PSFV）、时间平均流速（TMFV）和舒张末期流速（EDFV），并计算了搏动指数（PI =(PSFV - EDFV)/TMFV）和普氏阻力指数（RI =(PSFV - EDFV)/PSFV）。PSFV、TMFV和EDFV在妊娠晚期升高，与妊娠28周时的值相比，从妊娠36周起显著升高，提示实际脑血流量增加。在此期间，大脑中动脉的PI和RI无显著差异。出生后即刻，PSFV、TMFV和EDFV显著下降，与胎儿值相比，在出生后的前5天仍较低。大脑中动脉的PI和RI在出生后的第一天趋于下降，但随后稳定下来。
