煅烧介孔硅颗粒对小鼠组织细胞生物能量学的生物相容性。

Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues.

机构信息

Department of Immunology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates.

出版信息

Chem Res Toxicol. 2010 Nov 15;23(11):1796-805. doi: 10.1021/tx100245j. Epub 2010 Oct 20.

DOI:10.1021/tx100245j

PMID:20961102

Abstract

A novel in vitro system was developed to investigate the effects of two forms of calcined mesoporous silica particles (MCM41-cal and SBA15-cal) on cellular respiration of mouse tissues. O(2) consumption by lung, liver, kidney, spleen, and pancreatic tissues was unaffected by exposure to 200 μg/mL MCM41-cal or SBA15-cal for several hours. Normal tissue histology was confirmed by light microscopy. Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics.

摘要

研究开发了一种新型的体外系统，以研究两种形式的煅烧介孔硅颗粒（MCM41-cal 和 SBA15-cal）对小鼠组织细胞呼吸的影响。将肺、肝、肾、脾和胰腺组织暴露于 200μg/ml 的 MCM41-cal 或 SBA15-cal 数小时，其耗氧量并没有受到影响。通过光镜证实了正常组织的组织学。电子显微镜显示，研究组织中颗粒的细胞内积累明显。结果表明介孔硅与小鼠组织生物能量学具有合理的体外生物相容性。