Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Division of Lymphatic Biology, College of Medicine, Texas A&M Health Science Center, Temple, Texas 76504, USA.
Ann N Y Acad Sci. 2010 Oct;1207 Suppl 1(Suppl 1):E16-20. doi: 10.1111/j.1749-6632.2010.05710.x.
This minireview summarizes an oral presentation given at the National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health workshop "Lymphatics in the Digestive System: Physiology, Health, and Disease" in Bethesda, Maryland on November 3-4, 2009. The concepts of extrinsic and intrinsic pumps, as well as intrinsic and extrinsic flows, are discussed in relation to the lymph transport in mesenteric lymphatic vessels. Age-related alterations in the structure and regulatory mechanisms of lymph flow in mesenteric lymphatic vessels may provide the basis for their diminished ability to work during the periods of increased functional loads in them. The recent development of modern experimental tools provides the opportunity to extend the knowledge on lymph transport function of lymphatic vessels that is absolutely necessary to maintain fluid and macromolecular homeostasis and to provide a transportation route for lipids adsorbed in gut and to immune cells.
这篇综述总结了 2009 年 11 月 3 日至 4 日在马里兰州贝塞斯达举行的美国国立卫生研究院国家糖尿病、消化和肾脏疾病研究所“消化系统中的淋巴系统:生理学、健康与疾病”研讨会的口头报告。本文讨论了外在和内在泵以及内在和外在流动的概念与肠系膜淋巴管的淋巴转运之间的关系。肠系膜淋巴管中与年龄相关的淋巴流动结构和调节机制的改变,可能为其在功能负荷增加期间工作能力下降提供了基础。现代实验工具的最新发展为扩展对淋巴管淋巴转运功能的认识提供了机会,这对于维持液体和大分子的内环境稳定以及为肠道吸收的脂质和免疫细胞提供运输途径是绝对必要的。