Suppr超能文献

控制肠系膜淋巴管网中淋巴转运的基本机制。

Basic mechanisms controlling lymph transport in the mesenteric lymphatic net.

机构信息

Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Division of Lymphatic Biology, College of Medicine, Texas A&M Health Science Center, Temple, Texas 76504, USA.

出版信息

Ann N Y Acad Sci. 2010 Oct;1207 Suppl 1(Suppl 1):E16-20. doi: 10.1111/j.1749-6632.2010.05710.x.

Abstract

This minireview summarizes an oral presentation given at the National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health workshop "Lymphatics in the Digestive System: Physiology, Health, and Disease" in Bethesda, Maryland on November 3-4, 2009. The concepts of extrinsic and intrinsic pumps, as well as intrinsic and extrinsic flows, are discussed in relation to the lymph transport in mesenteric lymphatic vessels. Age-related alterations in the structure and regulatory mechanisms of lymph flow in mesenteric lymphatic vessels may provide the basis for their diminished ability to work during the periods of increased functional loads in them. The recent development of modern experimental tools provides the opportunity to extend the knowledge on lymph transport function of lymphatic vessels that is absolutely necessary to maintain fluid and macromolecular homeostasis and to provide a transportation route for lipids adsorbed in gut and to immune cells.

摘要

这篇综述总结了 2009 年 11 月 3 日至 4 日在马里兰州贝塞斯达举行的美国国立卫生研究院国家糖尿病、消化和肾脏疾病研究所“消化系统中的淋巴系统:生理学、健康与疾病”研讨会的口头报告。本文讨论了外在和内在泵以及内在和外在流动的概念与肠系膜淋巴管的淋巴转运之间的关系。肠系膜淋巴管中与年龄相关的淋巴流动结构和调节机制的改变,可能为其在功能负荷增加期间工作能力下降提供了基础。现代实验工具的最新发展为扩展对淋巴管淋巴转运功能的认识提供了机会,这对于维持液体和大分子的内环境稳定以及为肠道吸收的脂质和免疫细胞提供运输途径是绝对必要的。

相似文献

1
Basic mechanisms controlling lymph transport in the mesenteric lymphatic net.
Ann N Y Acad Sci. 2010 Oct;1207 Suppl 1(Suppl 1):E16-20. doi: 10.1111/j.1749-6632.2010.05710.x.
2
Contractile physiology of lymphatics.
Lymphat Res Biol. 2009;7(2):87-96. doi: 10.1089/lrb.2009.0007.
4
Hydrodynamic regulation of lymphatic transport and the impact of aging.
Pathophysiology. 2010 Sep;17(4):277-87. doi: 10.1016/j.pathophys.2009.09.002. Epub 2010 Mar 11.
5
TNFΔARE Mice Display Abnormal Lymphatics and Develop Tertiary Lymphoid Organs in the Mesentery.
Am J Pathol. 2017 Apr;187(4):798-807. doi: 10.1016/j.ajpath.2016.12.007. Epub 2017 Feb 6.
6
Physiologic aspects of lymphatic contractile function: current perspectives.
Ann N Y Acad Sci. 2002 Dec;979:178-87; discussion 188-96. doi: 10.1111/j.1749-6632.2002.tb04878.x.
9
Functional adaptation of bovine mesenteric lymphatic vessels to mesenteric venous hypertension.
Am J Physiol Regul Integr Comp Physiol. 2014 Jun 15;306(12):R901-7. doi: 10.1152/ajpregu.00185.2013. Epub 2014 Mar 26.
10
Aged lymphatic contractility: recent answers and new questions.
Lymphat Res Biol. 2013 Mar;11(1):2-13. doi: 10.1089/lrb.2013.0003.

引用本文的文献

1
Fatty acid nitroalkenes regulate intestinal lipid absorption.
J Lipid Res. 2025 Aug;66(8):100855. doi: 10.1016/j.jlr.2025.100855. Epub 2025 Jul 4.
5
Lymphatic Senescence: Current Updates and Perspectives.
Biology (Basel). 2021 Apr 3;10(4):293. doi: 10.3390/biology10040293.
7
Pathophysiology of aged lymphatic vessels.
Aging (Albany NY). 2019 Aug 28;11(16):6602-6613. doi: 10.18632/aging.102213.
8
Aged Lymphatic Vessels and Mast Cells in Perilymphatic Tissues.
Int J Mol Sci. 2017 May 3;18(5):965. doi: 10.3390/ijms18050965.
9
Histamine as an Endothelium-Derived Relaxing Factor in Aged Mesenteric Lymphatic Vessels.
Lymphat Res Biol. 2017 Jun;15(2):136-145. doi: 10.1089/lrb.2016.0062. Epub 2017 Apr 28.

本文引用的文献

1
Phasic contractions of rat mesenteric lymphatics increase basal and phasic nitric oxide generation in vivo.
Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1319-28. doi: 10.1152/ajpheart.00039.2009. Epub 2009 Aug 7.
2
Methods for lymphatic vessel culture and gene transfection.
Microcirculation. 2009 Oct;16(7):615-28. doi: 10.1080/10739680903120778.
3
Lymphatic vessels: pressure- and flow-dependent regulatory reactions.
Ann N Y Acad Sci. 2008;1131:100-9. doi: 10.1196/annals.1413.009.
4
Age-related alterations of active pumping mechanisms in rat thoracic duct.
Microcirculation. 2007 Nov-Dec;14(8):827-39. doi: 10.1080/10739680701444065.
5
Contraction-initiated NO-dependent lymphatic relaxation: a self-regulatory mechanism in rat thoracic duct.
J Physiol. 2006 Sep 15;575(Pt 3):821-32. doi: 10.1113/jphysiol.2006.115212. Epub 2006 Jun 29.
6
Regional variations of contractile activity in isolated rat lymphatics.
Microcirculation. 2004 Sep;11(6):477-92. doi: 10.1080/10739680490476033.
7
[Experimental detection of autochthonous automatism of lymph vessels].
Experientia. 1961 Jan 15;17:29-30. doi: 10.1007/BF02157935.
8
Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic duct.
J Physiol. 2002 May 1;540(Pt 3):1023-37. doi: 10.1113/jphysiol.2001.016642.
10
Pressure-flow relationships in isolated sheep prenodal lymphatic vessels.
Am J Physiol. 1994 Sep;267(3 Pt 2):H938-43. doi: 10.1152/ajpheart.1994.267.3.H938.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验