牛肠系膜淋巴管对肠系膜静脉高压的功能适应性。
Functional adaptation of bovine mesenteric lymphatic vessels to mesenteric venous hypertension.
机构信息
Michael E. DeBakey Institute, Texas A&M University, College Station, Texas; Department of Biomedical Engineering, Texas A&M University, College Station, Texas;
Department Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada;
出版信息
Am J Physiol Regul Integr Comp Physiol. 2014 Jun 15;306(12):R901-7. doi: 10.1152/ajpregu.00185.2013. Epub 2014 Mar 26.
Lymph flow is the primary mechanism for returning interstitial fluid to the blood circulation. Currently, the adaptive response of lymphatic vessels to mesenteric venous hypertension is not known. This study sought to determine the functional responses of postnodal mesenteric lymphatic vessels. We surgically occluded bovine mesenteric veins to create mesenteric venous hypertension to elevate mesenteric lymph flow. Three days after surgery, postnodal mesenteric lymphatic vessels from mesenteric venous hypertension (MVH; n = 7) and sham surgery (Sham; n = 6) group animals were evaluated and compared. Contraction frequency (MVH: 2.98 ± 0.75 min(-1); Sham: 5.42 ± 0.81 min(-1)) and fractional pump flow (MVH: 1.14 ± 0.30 min(-1); Sham: 2.39 ± 0.32 min(-1)) were significantly lower in the venous occlusion group. These results indicate that postnodal mesenteric lymphatic vessels adapt to mesenteric venous hypertension by reducing intrinsic contractile activity.
淋巴液流动是将组织间液回流到血液循环的主要机制。目前，尚不清楚淋巴管对肠系膜静脉高压的适应性反应。本研究旨在确定节后肠系膜淋巴管道的功能反应。我们通过手术阻塞牛肠系膜静脉以产生肠系膜静脉高压，从而增加肠系膜淋巴液流量。手术后 3 天，评估并比较来自肠系膜静脉高压（MVH；n=7）和假手术（Sham；n=6）组动物的节后肠系膜淋巴管道。收缩频率（MVH：2.98±0.75 min(-1)；Sham：5.42±0.81 min(-1)）和分泵流量（MVH：1.14±0.30 min(-1)；Sham：2.39±0.32 min(-1)）在静脉闭塞组显著降低。这些结果表明，节后肠系膜淋巴管道通过降低内在收缩活性来适应肠系膜静脉高压。
Zotero 插件