Uza G
Institute of Hygiene and Public Health, Cluj-Napoca, Romania.
J Hum Hypertens. 1990 Dec;4(6):687-91.
The decrease in arterial blood pressure in patients with essential arterial hypertension treated with clonidine is associated, in 88.9% of cases, with a rise in serum inorganic phosphorus. The increase of inorganic phosphorus in the serum of patients with hypophosphataemia, during clonidine therapy, is higher (P less than 0.001) than in hypertensive patients with normal values of serum phosphorus (P less than 0.01). This effect is more significant in overweight hypertensive patients (P less than 0.0005) than in normal weight hypertensives (P less than 0.02). No correlation was noted between the rise of serum inorganic phosphorus and the decrease in systolic and diastolic arterial blood pressure. The rise of serum phosphorus concentration in hypertensive patients is attributed to inhibition of insulin release and enhancement of growth-hormone secretion induced by clonidine.
用可乐定治疗的原发性高血压患者动脉血压下降，88.9%的病例与血清无机磷升高有关。可乐定治疗期间，低磷血症患者血清无机磷的升高幅度（P<0.001）高于血清磷值正常的高血压患者（P<0.01）。这种效应在超重高血压患者中（P<0.0005）比正常体重高血压患者中（P<0.02）更显著。血清无机磷升高与收缩压和舒张压下降之间未发现相关性。高血压患者血清磷浓度升高归因于可乐定诱导的胰岛素释放受抑制和生长激素分泌增强。
