Shiraishi H, Koizumi J, Ofuku K, Suzuki T, Saito K, Hori T, Ikuta T, Kase K, Hori M
Department of Psychiatry, University of Tsukuba, Ibaraki, Japan.
Jpn J Psychiatry Neurol. 1990 Dec;44(4):693-702. doi: 10.1111/j.1440-1819.1990.tb01646.x.
The anterior horn and lateral ventricular sizes of the brain CT were selected for measurement and comparison between 47 schizophrenic patients and 48 neurotic cases, which constituted the control subjects. The ventricular brain ratio (VBR) and the linear ratio (LR 1-6) in multiple age groups were calculated, analyzed and compared using the Student's t test, the two-way ANOVA and Bonferroni's methods. It was found that the VBR of the anterior horn and modified bicaudate cerebroventricular index of the teenage schizophrenics were significantly greater than those of the teenage controls (p less than 0.01) and the ventricular sizes were not associated with the different stages of age except for the cases of the teenage group. These results support the hypothesis of previous investigators that the ventricular enlargement is present early in the course of schizophrenia and provide additional evidence that in teenage schizophrenic patients there is a tendency of the enlargement of the anterior horn of the lateral ventricle which may be related with a morphological vulnerability in the prefrontal cortex.
选取47例精神分裂症患者和48例神经症患者（作为对照对象）的脑部CT前角和侧脑室大小进行测量与比较。采用学生t检验、双向方差分析和邦费罗尼方法计算、分析并比较多个年龄组的脑室脑比率（VBR）和线性比率（LR 1 - 6）。结果发现，青少年精神分裂症患者的前角VBR和改良双尾状核脑室指数显著高于青少年对照组（p < 0.01），除青少年组外，脑室大小与不同年龄阶段无关。这些结果支持了先前研究者的假设，即精神分裂症病程早期存在脑室扩大，并提供了额外证据表明青少年精神分裂症患者侧脑室前角有扩大趋势，这可能与前额叶皮质的形态易损性有关。
