Sadowski Z, Pietrzyk E, Purzycki Z, Hoffman M, Sitkowski W, Bednarska M
Instytutu Kardiologii, Warszawie.
Kardiol Pol. 1990;33(11-2):5-10.
A group of 43 patients (pts) from a larger group 451 pts with coronary artery disease (CAD) confirmed by coronary angiography were recatheterized because of deterioration of symptoms. After the first angiography patients had no indications to coronary artery bypass grafting (CABG) or gave no consent to surgery. The group comprised 3 women and 40 men aged 27 to 62 years (mean age 45 +/- 8 years). The mean interval between coronarography was 35 +/- 22 months. Four independent reviewers evaluated 15 segments of coronary arteries according to American Heart Association. The coronary lesions were scored on the basis of reduction in luminal diameter as follows: 0 point = 0-29%, 1 = 30-49%, 2 = 50-69%, 3 = 70-98%, 4 = 90-99%, 5 = 100% occlusion. The influence of the following risk factors on the progression was evaluated: age, sex, hypertension, diabetes, lipid disturbances, smoking, hyperuricaemia, family history. The patients were divided into 3 groups: group I--no or slight progression (0 to 4 points) in two successive coronary angiographies, group II--moderate progression (5 to 9 points) and group II--significant progression (10 points or more). The number of patients in these groups was 14, 12 and 17 respectively. In such isolated groups, the clinical events were compared: unstable angina, myocardial infarctions, need for CABG, cardiac deaths within follow-up period. The ejection fraction of the left ventricle was also evaluated.
was conducted by multiple regression model.(ABSTRACT TRUNCATED AT 250 WORDS)
在一组451例经冠状动脉造影确诊为冠心病（CAD）的患者中，有43例患者因症状恶化接受了再次导管检查。首次血管造影后，这些患者没有冠状动脉旁路移植术（CABG）的指征或未同意手术。该组包括3名女性和40名男性，年龄在27至62岁之间（平均年龄45±8岁）。冠状动脉造影的平均间隔时间为35±22个月。4名独立的评估者根据美国心脏协会的标准对15段冠状动脉进行了评估。根据管腔直径缩小情况对冠状动脉病变进行评分如下：0分=0 - 29%，1分=30 - 49%，2分=50 - 69%，3分=70 - 98%，4分=90 - 99%，5分=100%闭塞。评估了以下危险因素对病情进展的影响：年龄、性别、高血压、糖尿病、血脂紊乱、吸烟、高尿酸血症、家族史。患者被分为3组：I组——两次连续冠状动脉造影中无进展或进展轻微（0至4分），II组——中度进展（5至9分），III组——显著进展（10分或更高）。这些组中的患者人数分别为14、12和17。在这些独立的组中，比较了临床事件：不稳定型心绞痛、心肌梗死、CABG需求、随访期内心脏死亡。还评估了左心室射血分数。
采用多元回归模型进行。（摘要截断于250字）
