病毒载量和CD4 +细胞计数作为HIV感染患者QT间期延长的危险因素：一项门诊人群队列嵌套病例对照研究。
Viral load and CD4+ cell count as risk factors for prolonged QT interval in HIV-infected subjects: a cohort-nested case-control study in an outpatient population.
作者信息
Qaqa Ashraf Y, Shaaban Hamid, DeBari Vincent A, Phung Suzan, Slim Jihad, Costeas Constantinos A, Perez George, Shamoon Fayez E
机构信息
Department of Internal Medicine, School of Health and Medical Sciences, Seton Hall University, Newark, N.J., USA.
出版信息
Cardiology. 2010;117(2):105-11. doi: 10.1159/000320216. Epub 2010 Oct 21.
BACKGROUND
QTc interval prolongation is a serious ECG finding which has frequently been reported in HIV-infected patients, but associated risk factors have not been determined in this population.
METHODS
Data were collected from the charts of a cohort of 135 consecutive HIV-infected patients from our HIV outpatient clinic. The cohort was divided into two groups, patients with prolonged QTc and those with normal QTc interval. Multiple variables and potential risk factors were analyzed, including the CD4+ cell count and viral load (VL), which were assessed on the same day or within several days of the initial ECG.
RESULTS
23 patients were found to have prolonged QTc (17%). No significant difference in baseline characteristics was observed between the groups; however, statistically significant differences were observed with regard to the CD4+ cell count and VL.
CONCLUSION
A low CD4 cell count and a high VL may be risk factors potentially related to QT prolongation in HIV patients in the outpatient setting.
背景
QTc间期延长是一种严重的心电图表现，在HIV感染患者中经常有报道，但该人群中相关的危险因素尚未确定。
方法
从我们HIV门诊连续135例HIV感染患者的病历中收集数据。该队列分为两组，QTc延长患者和QTc间期正常患者。分析了多个变量和潜在危险因素，包括CD4+细胞计数和病毒载量（VL），这些指标在首次心电图检查的同一天或几天内进行评估。
结果
发现23例患者QTc延长（17%）。两组间基线特征未观察到显著差异；然而，在CD4+细胞计数和VL方面观察到统计学显著差异。
结论
在门诊环境中，低CD4细胞计数和高VL可能是与HIV患者QT延长潜在相关的危险因素。
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