Department of Respiratory Medicine, The Second Affiliated Hospital, Nanjing Medical University, PR China.
Can J Physiol Pharmacol. 2010 Oct;88(10):1010-6. doi: 10.1139/y10-077.
Paeonol, the main active component isolated from Moutan Cortex, possesses extensive pharmacological activities such as anti-inflammatory, anti-allergic, and immunoregulatory effects. In the present study, we examined the effects of paeonol on airway inflammation and hyperresponsiveness in a mouse model of allergic asthma. BALB/c mice sensitized and challenged with ovalbumin were administered paeonol intragastrically at a dose of 100 mg/kg daily. Paeonol significantly suppressed ovalbumin-induced airway hyperresponsiveness to acetylcholine chloride. Paeonol administration significantly inhibited the total inflammatory cell and eosinophil count in bronchoalveolar lavage fluid. Treatment with paeonol significantly enhanced IFN-γ levels and decreased interleukin-4 and interleukin-13 levels in bronchoalveolar lavage fluid and total immunoglobulin E levels in serum. Histological examination of lung tissue demonstrated that paeonol significantly attenuated allergen-induced lung eosinophilic inflammation and mucus-producing goblet cells in the airway. These data suggest that paeonol exhibits anti-inflammatory activity in allergic mice and may possess new therapeutic potential for the treatment of allergic bronchial asthma.
丹皮酚是从牡丹皮中分离得到的主要活性成分，具有广泛的药理活性，如抗炎、抗过敏和免疫调节作用。在本研究中，我们研究了丹皮酚对卵清蛋白诱导的过敏性哮喘小鼠模型气道炎症和高反应性的影响。用卵清蛋白致敏和攻击 BALB/c 小鼠，每天用 100mg/kg 的丹皮酚灌胃。丹皮酚显著抑制卵清蛋白诱导的乙酰胆碱氯气道高反应性。丹皮酚给药显著抑制支气管肺泡灌洗液中总炎性细胞和嗜酸性粒细胞计数。丹皮酚治疗显著增加了支气管肺泡灌洗液中 IFN-γ 水平，降低了白细胞介素-4 和白细胞介素-13 水平，以及血清中总免疫球蛋白 E 水平。肺组织的组织学检查表明，丹皮酚显著减轻了变应原诱导的肺嗜酸性粒细胞炎症和气道中产生粘液的杯状细胞。这些数据表明丹皮酚在过敏性小鼠中具有抗炎活性，可能为治疗过敏性支气管哮喘提供新的治疗潜力。
