Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Med Phys. 2010 Sep;37(9):4733-43. doi: 10.1118/1.3478278.
To evaluate the dose distributions of an 192Ir source (model VS2000) in homogeneous water geometry calculated using a deterministic grid-based Boltzmann transport equation solver (GBBS) in the commercial treatment planning system (TPS) (BRACHYVISION-ACUROS V8.8).
Using percent dose differences (%deltaD), the GBBS (BV-ACUROS) was compared to the (1) published TG-43 data, (2) MCNPX Monte Carlo (MC) simulations of the 192Ir source centered in a 15 cm radius water sphere, and (3) TG-43 output from the TPS using vendor supplied (BV-TG43-vendor) and user extended (BV-TG43-extended) 2D anisotropy functions F(r, theta). BV-ACUROS assumes 1 mm of NiTi cable, while the TPS TG-43 algorithm uses data based on a 15 cm cable. MC models of various cable lengths were simulated.
The MC simulations resulted in > 20% dose deviations along the cable for 1, 2, and 3 mm cable lengths relative to 15 cm. BV-ACUROS comparisons with BV-TG43-vendor and BV-TG43-extended yielded magnitude of differences, consistent with those seen in MC simulations. However, differences > 20% extended further (theta < or = 10 degrees) when using the vendor supplied anisotropy function F(ven0(r, theta). These differences were also seen in comparisons of F(r, theta) derived from the TPS output.
The results suggest that %deltaD near the cable region is larger than previously estimated. The spatial distribution of the dose deviation is highly dependent on the reference TG-43 data used to compare to GBBS. The differences observed, while important to realize, should not have an impact on clinical dosimetry in homogeneous water.
评估在商业治疗计划系统(BRACHYVISION-ACUROS V8.8)中的确定性网格玻尔兹曼输运方程求解器(GBBS)中计算的均匀水几何形状中的 192Ir 源(型号 VS2000)的剂量分布。
使用百分剂量差异(%deltaD),将 GBBS(BV-ACUROS)与(1)已发表的 TG-43 数据、(2)以 15 厘米半径水球为中心的 192Ir 源的 MCNPX 蒙特卡罗(MC)模拟以及(3)来自治疗计划系统的 TG-43 输出进行比较,该输出使用供应商提供的(BV-TG43-vendor)和用户扩展的(BV-TG43-extended)二维各向异性函数 F(r,theta)。BV-ACUROS 假设 1 毫米的 NiTi 电缆,而 TPS TG-43 算法使用基于 15 厘米电缆的数据。模拟了各种电缆长度的 MC 模型。
与 15 厘米相比,MC 模拟导致沿电缆出现超过 20%的剂量偏差,对于 1、2 和 3 毫米的电缆长度。BV-ACUROS 与 BV-TG43-vendor 和 BV-TG43-extended 的比较产生了与 MC 模拟中看到的一致的差异幅度。然而,当使用供应商提供的各向异性函数 F(ven0(r,theta)时,差异超过 20%进一步扩展(theta <= 10 度)。这些差异也出现在从 TPS 输出派生的 F(r,theta)的比较中。
结果表明,靠近电缆区域的%deltaD 大于先前估计的值。剂量偏差的空间分布高度依赖于用于与 GBBS 比较的参考 TG-43 数据。观察到的差异虽然重要,但不应对均匀水的临床剂量学产生影响。