Food Science and Human Nutrition, University of Maine, Orono, Maine 04469, USA.
J Agric Food Chem. 2010 Nov 24;58(22):11600-5. doi: 10.1021/jf101839u. Epub 2010 Oct 22.
The effect of a wild blueberry-enriched diet on vasoconstriction and vasorelaxation was examined in the adult, 20-week-old spontaneously hypertensive rat (SHR) after 8 weeks of a control (C) or an 8% wild blueberry (WB) diet. Nitric oxide (NO)- and cyclooxygenase (COX)-mediated aortic responses were examined ex vivo with the agonists L-phenylephrine (Phe) and acetylcholine (Ach), in the absence or presence of the NO synthase (NOS) inhibitor L-NG-monomethyl arginine (L-NMMA) or the COX inhibitor mefenamic acid (MFA). The vasoconstriction elicited by Phe was reduced in the WB group, attributed to the NO pathway, favoring a lower vascular tone under basal conditions. Acetylcholine-induced vasorelaxation in the WB group was possibly mediated through the COX, but not the NO pathway. These findings document the potential of wild blueberries to modify major pathways of vasomotor control and improve the vascular tone in the adult SHR with endothelial dysfunction.
在成年自发性高血压大鼠（SHR）中，研究了富含野生蓝莓的饮食对血管收缩和血管舒张的影响，实验时间为 8 周的对照（C）或 8%野生蓝莓（WB）饮食。通过使用 L-苯肾上腺素（Phe）和乙酰胆碱（Ach）作为激动剂，在不存在或存在一氧化氮合酶（NOS）抑制剂 L-NG-单甲基精氨酸（L-NMMA）或环氧化酶（COX）抑制剂甲芬那酸（MFA）的情况下，在离体条件下检查了主动脉的 NO 和 COX 介导的反应。在 WB 组中，Phe 引起的血管收缩减少，归因于 NO 途径，在基础条件下有利于较低的血管张力。WB 组中乙酰胆碱引起的血管舒张可能通过 COX 介导，而不是通过 NO 途径。这些发现证明了野生蓝莓具有调节主要血管运动控制途径和改善成年伴有内皮功能障碍的 SHR 血管张力的潜力。
