Seliger E, Kaltwasser P, Schneider F, Rothe K, Buchmann J
Universitäts-Frauenklinik, Martin-Luther-Universität, Halle-Wittenberg.
Ther Umsch. 1990 Dec;47(12):945-50.
In 35 patients with laparoscopically proved endometriosis we determined the cytosolic estrogen and progesterone receptor content in endometrial samples before and after a 3-month course of progestagen treatment (DCC method). Dienogest was given in 20 cases, norethisterone in an other group of 15 patients. Compared with a normal group the receptor content was clearly higher in endometriosis patients. It correlated closely to the histological findings dated according to Noyes. In more than 60% of the pretherapeutic cycles there were some signs of disturbed differentiation. After 3 month of therapy the binding capacity of steroid receptors significantly decreased, particularly in norethisterone patients. Both clinical results and receptor conditions correspond to previous investigations concerning the competition behaviour, having confirmed different binding affinity to the receptor for the two gestagens here tested.
在35例经腹腔镜证实患有子宫内膜异位症的患者中，我们采用葡聚糖包被活性炭法（DCC法）测定了3个月孕激素治疗前后子宫内膜样本中细胞溶质雌激素和孕激素受体的含量。20例患者给予地诺孕素，另一组15例患者给予炔诺酮。与正常组相比，子宫内膜异位症患者的受体含量明显更高。它与根据诺伊斯标准确定的组织学结果密切相关。在超过60%的治疗前周期中存在一些分化紊乱的迹象。治疗3个月后，类固醇受体的结合能力显著下降，尤其是炔诺酮治疗的患者。临床结果和受体状况均与先前关于竞争行为的研究一致，证实了在此测试的两种孕激素对受体具有不同的结合亲和力。
