肌钙蛋白 T 异构体和转录后修饰：进化、调节和功能。
Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function.
机构信息
Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
出版信息
Arch Biochem Biophys. 2011 Jan 15;505(2):144-54. doi: 10.1016/j.abb.2010.10.013. Epub 2010 Oct 18.
Abstract
Troponin-mediated Ca²(+)-regulation governs the actin-activated myosin motor function which powers striated (skeletal and cardiac) muscle contraction. This review focuses on the structure-function relationship of troponin T, one of the three protein subunits of the troponin complex. Molecular evolution, gene regulation, alternative RNA splicing, and posttranslational modifications of troponin T isoforms in skeletal and cardiac muscles are summarized with emphases on recent research progresses. The physiological and pathophysiological significances of the structural diversity and regulation of troponin T are discussed for impacts on striated muscle function and adaptation in health and diseases.
摘要
肌钙蛋白介导的 Ca²+(+)调节控制肌球蛋白马达功能，从而产生横纹肌（骨骼肌和心肌）的收缩。本综述重点介绍了肌钙蛋白复合物三个蛋白亚基之一肌钙蛋白 T 的结构-功能关系。总结了骨骼肌和心肌肌钙蛋白 T 异构体的分子进化、基因调控、选择性 RNA 剪接和翻译后修饰，并强调了最新的研究进展。讨论了肌钙蛋白 T 的结构多样性和调节的生理和病理生理学意义，以了解其对横纹肌功能和健康与疾病适应的影响。
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