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1
Back to the future: new techniques show that forgotten phosphorylation sites are present in contractile proteins of the heart whilst intensively studied sites appear to be absent.回到未来：新技术表明，心脏收缩蛋白中存在被遗忘的磷酸化位点，而深入研究的位点似乎并不存在。
J Muscle Res Cell Motil. 2009;30(3-4):93-5. doi: 10.1007/s10974-009-9184-y. Epub 2009 Jul 25.
2
Cardiac function and phosphorylation of contractile proteins.心脏功能与收缩蛋白的磷酸化
Philos Trans R Soc Lond B Biol Sci. 1983 Jul 5;302(1108):83-90. doi: 10.1098/rstb.1983.0040.
3
Effects of contractile protein phosphorylation on force development in permeabilized rat cardiac myocytes.收缩蛋白磷酸化对通透大鼠心肌细胞中力产生的影响。
Basic Res Cardiol. 2007 Nov;102(6):476-87. doi: 10.1007/s00395-007-0663-2. Epub 2007 Jun 5.
4
Preconditioning and limitation of stunning: one step closer to the protected protein(s)?预处理与心肌顿抑的限制：向受保护蛋白（们）更近一步？
Cardiovasc Res. 1999 Jun;42(3):571-5. doi: 10.1016/s0008-6363(99)00086-3.
5
Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins.晚期人类心力衰竭中收缩装置对钙离子敏感性增加是由收缩蛋白磷酸化改变所致。
Cardiovasc Res. 2003 Jan;57(1):37-47. doi: 10.1016/s0008-6363(02)00606-5.
6
Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure.肌钙蛋白磷酸化及在人心脏肌肉中的调节功能：肌钙蛋白I上Ser23/24的去磷酸化可能是终末期心力衰竭收缩功能缺陷的原因。
J Mol Cell Cardiol. 2007 Jan;42(1):247-59. doi: 10.1016/j.yjmcc.2006.08.017. Epub 2006 Nov 1.
7
Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy.导致肥厚型心肌病的突变收缩蛋白的特性。
Cardiovasc Res. 1999 Oct;44(1):20-36. doi: 10.1016/s0008-6363(99)00213-8.
8
Cyclic-AMP-dependent phosphorylation of cardiac contractile proteins.心脏收缩蛋白的环磷酸腺苷依赖性磷酸化
Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984;17:383-90.
9
Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis.脓毒症期间心肌肌原纤维蛋白的磷酸化和钙敏感性改变。
Am J Physiol Regul Integr Comp Physiol. 2001 Aug;281(2):R408-16. doi: 10.1152/ajpregu.2001.281.2.R408.
10
Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylation.心脏低血流量期间力产生减少与肌钙蛋白I磷酸化改变相关。
J Muscle Res Cell Motil. 2009;30(3-4):111-23. doi: 10.1007/s10974-009-9180-2. Epub 2009 Jun 9.

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1
Role of the interaction between troponin T and AMP deaminase by zinc bridge in modulating muscle contraction and ammonia production.肌钙蛋白 T 与 AMP 脱氨酶通过锌桥相互作用在调节肌肉收缩和氨生成中的作用。
Mol Cell Biochem. 2024 Apr;479(4):793-809. doi: 10.1007/s11010-023-04763-7. Epub 2023 May 15.
2
Defining the Sarcomeric Proteoform Landscape in Ischemic Cardiomyopathy by Top-Down Proteomics.通过自上而下的蛋白质组学定义缺血性心肌病中的肌节蛋白构象景观。
J Proteome Res. 2023 Mar 3;22(3):931-941. doi: 10.1021/acs.jproteome.2c00729. Epub 2023 Feb 17.
3
Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics.不同肥厚型心肌病基因型导致的相似肌节蛋白构象表型可通过自上而下的蛋白质组学技术揭示。
Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):24691-24700. doi: 10.1073/pnas.2006764117. Epub 2020 Sep 23.
4
The role of protein kinase C-mediated phosphorylation of sarcomeric proteins in the heart-detrimental or beneficial?蛋白激酶C介导的肌节蛋白磷酸化在心脏中起有害还是有益作用？
Biophys Rev. 2011 Sep;3(3):107. doi: 10.1007/s12551-011-0050-y. Epub 2011 Jun 28.
5
Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.研究肌钙蛋白 I 磷酸化与肌球蛋白纤维 Ca(2+)敏感性变化解偶联在心肌病发病机制中的作用。
Front Physiol. 2014 Aug 25;5:315. doi: 10.3389/fphys.2014.00315. eCollection 2014.
6
Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium.肌球蛋白纤维蛋白的翻译后修饰在兔右心室心肌长度依赖性舒张延长中的作用。
Arch Biochem Biophys. 2013 Jul 1;535(1):22-9. doi: 10.1016/j.abb.2012.10.005. Epub 2012 Oct 19.
7
Augmented phosphorylation of cardiac troponin I in hypertensive heart failure.高血压性心力衰竭中心肌肌钙蛋白 I 的磷酸化增强。
J Biol Chem. 2012 Jan 6;287(2):848-57. doi: 10.1074/jbc.M111.293258. Epub 2011 Nov 3.
8
Structure of the NH2-terminal variable region of cardiac troponin T determines its sensitivity to restrictive cleavage in pathophysiological adaptation.肌钙蛋白 T 的 NH2-末端可变区结构决定了其在病理生理适应过程中对限制性切割的敏感性。
Arch Biochem Biophys. 2011 Nov;515(1-2):37-45. doi: 10.1016/j.abb.2011.08.013. Epub 2011 Sep 5.
9
Signaling and myosin-binding protein C.信号转导和肌球蛋白结合蛋白 C。
J Biol Chem. 2011 Mar 25;286(12):9913-9. doi: 10.1074/jbc.R110.171801. Epub 2011 Jan 21.
10
Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function.肌钙蛋白 T 异构体和转录后修饰：进化、调节和功能。
Arch Biochem Biophys. 2011 Jan 15;505(2):144-54. doi: 10.1016/j.abb.2010.10.013. Epub 2010 Oct 18.

本文引用的文献

1
Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.β受体阻滞剂治疗对心肌梗死后重构中肌丝功能障碍的预防作用
Circ Heart Fail. 2009 May;2(3):233-42. doi: 10.1161/CIRCHEARTFAILURE.108.806125. Epub 2009 Mar 25.
2
Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry.通过自上而下串联质谱法揭示大鼠心肌肌钙蛋白中的单氨基酸序列多态性。
J Muscle Res Cell Motil. 2008;29(6-8):203-12. doi: 10.1007/s10974-009-9168-y. Epub 2009 Jan 23.
3
Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?心力衰竭时肌钙蛋白磷酸化与肌丝钙敏感性：是增加还是降低？
J Mol Cell Cardiol. 2008 Nov;45(5):603-7. doi: 10.1016/j.yjmcc.2008.07.004. Epub 2008 Jul 19.
4
Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle.正常、肥厚和衰竭的人类心肌中肌球蛋白结合蛋白C的磷酸化
J Mol Cell Cardiol. 2008 Aug;45(2):209-16. doi: 10.1016/j.yjmcc.2008.05.020. Epub 2008 Jun 4.
5
Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry.通过自上而下的电子捕获解离/电子转移解离质谱法揭示磷酸化人心脏肌钙蛋白I的分子复杂性。
Mol Cell Proteomics. 2008 Oct;7(10):1838-49. doi: 10.1074/mcp.M700524-MCP200. Epub 2008 Apr 28.
6
Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure.肌钙蛋白磷酸化及在人心脏肌肉中的调节功能：肌钙蛋白I上Ser23/24的去磷酸化可能是终末期心力衰竭收缩功能缺陷的原因。
J Mol Cell Cardiol. 2007 Jan;42(1):247-59. doi: 10.1016/j.yjmcc.2006.08.017. Epub 2006 Nov 1.
7
Myosin binding protein C is differentially phosphorylated upon myocardial stunning in canine and rat hearts-- evidence for novel phosphorylation sites.肌球蛋白结合蛋白C在犬和大鼠心脏心肌顿抑时发生差异磷酸化——新磷酸化位点的证据
Proteomics. 2006 Jul;6(14):4176-86. doi: 10.1002/pmic.200500894.
8
Regulation of cardiac contractile function by troponin I phosphorylation.肌钙蛋白I磷酸化对心脏收缩功能的调节
Cardiovasc Res. 2005 Apr 1;66(1):12-21. doi: 10.1016/j.cardiores.2004.12.022.
9
Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T.鉴定心肌肌钙蛋白T功能关键的蛋白激酶C磷酸化残基
J Biol Chem. 2003 Sep 12;278(37):35135-44. doi: 10.1074/jbc.M306325200. Epub 2003 Jun 28.
10
Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins.晚期人类心力衰竭中收缩装置对钙离子敏感性增加是由收缩蛋白磷酸化改变所致。
Cardiovasc Res. 2003 Jan;57(1):37-47. doi: 10.1016/s0008-6363(02)00606-5.

Back to the future: new techniques show that forgotten phosphorylation sites are present in contractile proteins of the heart whilst intensively studied sites appear to be absent.

作者信息

Marston Steven B, Walker Jeffrey W

机构信息

Imperial College London, London SW36LY, UK.

出版信息

J Muscle Res Cell Motil. 2009;30(3-4):93-5. doi: 10.1007/s10974-009-9184-y. Epub 2009 Jul 25.

DOI:10.1007/s10974-009-9184-y
PMID:19633912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2734264/
Abstract
摘要