Department of Psychiatry, Songshan Armed Forces General Hospital, Taipei, Taiwan 105, Republic of China.
Compr Psychiatry. 2010 Nov-Dec;51(6):557-65. doi: 10.1016/j.comppsych.2010.03.007. Epub 2010 Apr 24.
Personal beliefs about medication compliance have been reliably associated with emotional and behavioral response to mental health problems and health outcomes. This notion has been extensively explored in relation to mental illness. In the current study, a questionnaire designed to assess beliefs about medication compliance (the medication adherence rating scale [MARS]) was translated into Taiwanese to explore beliefs about compliance in schizophrenic patients.
In this cross-sectional study, 104 patients who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for schizophrenic disorders were recruited and independently interviewed. We first determined the psychometric properties of the translated MARS, including internal consistency, test-retest reliability, and construct validity. In addition, we investigated the relationships between medication compliance and clinical variables through correlation and regression analyses.
We found that the translated MARS was a simple and reliable self-reported compliance scale. Furthermore, in this exploratory study, we found that patients with better medication compliance had better insight into mental illness, less severe psychopathologic condition, and less negative subjective response to side effects of antipsychotics.
Additional research focusing on these patient outcomes will be of great interest and value in elucidating the role of medication compliance in management of schizophrenic patients.
个人对药物治疗的信念与对心理健康问题和健康结果的情绪和行为反应密切相关。这一概念已在精神疾病方面得到了广泛的探讨。在本研究中，设计了一个评估药物治疗依从性信念的问卷（药物依从性评定量表 [MARS]），并将其翻译成中文，以探讨精神分裂症患者的药物治疗依从性信念。
本横断面研究共纳入 104 名符合精神障碍诊断与统计手册第 4 版精神分裂症标准的患者，并对其进行独立访谈。我们首先确定了翻译后的 MARS 的心理测量学特性，包括内部一致性、重测信度和结构效度。此外，我们通过相关和回归分析调查了药物治疗依从性与临床变量之间的关系。
我们发现，翻译后的 MARS 是一个简单可靠的自我报告依从性量表。此外，在这项探索性研究中，我们发现药物治疗依从性较好的患者对精神疾病的认识更好，精神病理状况较轻，对抗精神病药物副作用的主观负面反应较轻。
关注这些患者结局的进一步研究对于阐明药物治疗依从性在精神分裂症患者管理中的作用将具有重要的意义和价值。
