Ciaroni S, Cecchini T, Battelli F, Del Grande P
Istituto di Scienze Morfologiche, Università di Urbino, Italy.
Z Mikrosk Anat Forsch. 1990;104(6):898-906.
The reduction of the forceps major of the corpus callosum was estimated quantitatively in relation to the lesions to the neocortex in animals to which methylazoxymethanol-acetate (MAM) had been administered on the 13 th, 15 th or 17 th day of embryonic development. The specimens which received a prenatal injection of MAM the 13 th or 15 the day of gestation show noticeable reductions in both the extension of the occipital neocortex and the forceps major of the corpus callosum. Parallelly in MAM 13 there is a significant reduction in cell density both in the deeper layers and the more superficial ones, whereas in MAM 15 only the supragranular layers seem to be altered. Such a quantitative analysis shows a close correlation among the decreases in the area of the forceps major of the corpus callosum, in the area of the occipital neocortex and in cell density of the infragranular and supragranular layers.
在胚胎发育第13、15或17天给动物注射乙酸甲基氧化偶氮甲醇（MAM），定量评估胼胝体钳状束减少与新皮质损伤的关系。在妊娠第13天或15天接受产前MAM注射的标本，枕叶新皮质的范围和胼胝体钳状束均有明显减少。同时，在MAM 13组，深层和浅层的细胞密度均显著降低，而在MAM 15组，似乎只有颗粒上层发生改变。这种定量分析表明，胼胝体钳状束面积、枕叶新皮质面积以及颗粒下层和颗粒上层细胞密度的降低之间存在密切相关性。
