Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
AJR Am J Roentgenol. 2010 Nov;195(5):1241-4. doi: 10.2214/AJR.10.4401.
Partial splenic embolization has been used for more than 20 years to manage thrombocytopenia secondary to hypersplenism. Both temporary and permanent embolic agents have been used without definition of an optimal agent. The purposes of this report are to describe the use of the Onyx nonadhesive liquid embolization system to treat three patients with severe hypersplenism precluding administration of systemic chemotherapy and to report on the hematologic response and clinical outcome after partial splenic embolization with this agent.
The platelet counts of three patients treated by partial splenic embolization with the Onyx agent improved sufficiently for administration of systemic chemotherapy. In addition, severe postembolization syndrome, a common occurrence after partial splenic embolization, did not occur in our patient population.
部分脾栓塞术已应用 20 余年，用于治疗脾功能亢进引起的血小板减少症。无论是临时还是永久性栓塞剂，都有应用，但没有定义最佳的栓塞剂。本报告的目的是描述使用 Onyx 非粘附性液体栓塞系统治疗 3 例因严重脾功能亢进而不能接受全身化疗的患者，并报告使用该药物进行部分脾栓塞后的血液学反应和临床结果。
3 例接受 Onyx 药物部分脾栓塞治疗的患者的血小板计数足以进行全身化疗。此外，我们的患者群体中没有出现部分脾栓塞后常见的严重栓塞后综合征。
