局部缺氧对心率的影响。

Effect of local anaerobiosis on heart rate.

作者信息

Thimm F

机构信息

Physiologisches Institut, Universität Freiburg, F.R.G.

出版信息

Adv Exp Med Biol. 1990;277:459-66. doi: 10.1007/978-1-4684-8181-5_51.

DOI:10.1007/978-1-4684-8181-5_51

PMID:2096648

Abstract

The isolated leg of a rat was connected to the body only by nerve and bone and was perfused with hypoxic Tyrode solution. Heart rate increased when metabolic parameters (PCO2, pH and lactate) reached values similar to those observed at the beginning of exercise. When the muscle was additionally stimulated by electric stimuli a significant temporal correlation between lactate and heart or respiratory rate was found. Metabolic changes caused by hypoxia and muscular contraction, in particular lactic acid, appear to act as chemical stimuli for metabolic muscle receptors participating in the generation of circulatory and respiratory responses to physical exercise.

摘要

大鼠的离体腿仅通过神经和骨骼与身体相连，并用缺氧的台氏液灌注。当代谢参数（PCO2、pH值和乳酸）达到与运动开始时观察到的值相似时，心率增加。当肌肉受到电刺激时，发现乳酸与心率或呼吸频率之间存在显著的时间相关性。缺氧和肌肉收缩引起的代谢变化，特别是乳酸，似乎作为化学刺激物作用于参与对体育锻炼产生循环和呼吸反应的代谢性肌肉感受器。