Laboratory of Tissue Engineering, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.
ASAIO J. 2010 Nov-Dec;56(6):563-8. doi: 10.1097/MAT.0b013e3181fcbe24.
Hydrogels prepared from a mixture of fibrin and high-molecular weight (MW) hyaluronic acid (HA) were found to be suitable scaffolds for chondrocyte seeding and pig knee cartilage regeneration. Collagen in the hydrogels is not necessary for the formation of biomechanically stable tissue. Regenerated cartilage showed very good biomechanical and histological properties only 6 months after implantation. Notably, the quality of the healing process was dependent on the initial chondrocyte concentration of the scaffolds. These experiments were performed according to good laboratory practice (GLP).
由纤维蛋白和高分子量（MW）透明质酸（HA）混合物制备的水凝胶被发现是适合用于软骨细胞接种和猪膝关节软骨再生的支架。水凝胶中的胶原对于形成具有生物力学稳定性的组织不是必需的。在植入后仅 6 个月，再生的软骨就表现出非常好的生物力学和组织学特性。值得注意的是，愈合过程的质量取决于支架的初始软骨细胞浓度。这些实验是根据良好实验室规范（GLP）进行的。
