Brashear A
Department of Neurology, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA.
Drugs Today (Barc). 2010 Sep;46(9):671-82. doi: 10.1358/dot.2010.46.9.1524356.
The use of botulinum toxin has expanded in the last five years to include traditional neurological use against dystonia and spasticity, as well as the emerging use for headache, pain, neuropathy, myofascial pain, joint arthritis, otolaryngology, gastroenterology and genitourinary disorders. This review will focus on these emerging uses of botulinum toxin as reported in recent literature. The exploratory use of botulinum toxin for cervical dystonia, blepharospasm and spasticity in small trials and case reports, has led to its detailed study in larger placebo-controlled clinical trials. Although the use of botulinum toxin for new indications may benefit a specific subset of patients with refractory pain and disability, the reader must realize that this is an emerging area, generally limited by a lack of large, placebo-controlled studies.
在过去五年中，肉毒杆菌毒素的应用范围不断扩大，涵盖了传统的针对肌张力障碍和痉挛的神经学用途，以及在头痛、疼痛、神经病变、肌筋膜疼痛、关节关节炎、耳鼻喉科、胃肠病学和泌尿生殖系统疾病等方面的新用途。本综述将聚焦于近期文献中报道的肉毒杆菌毒素的这些新用途。在小型试验和病例报告中，肉毒杆菌毒素用于治疗颈部肌张力障碍、眼睑痉挛和痉挛的探索性应用，促使其在更大规模的安慰剂对照临床试验中得到详细研究。尽管将肉毒杆菌毒素用于新适应症可能使特定的难治性疼痛和残疾患者群体受益，但读者必须认识到，这是一个新兴领域，通常因缺乏大型安慰剂对照研究而受到限制。
