Chin Jeannie
Department of Neuroscience and Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA, USA.
Methods Mol Biol. 2011;670:169-89. doi: 10.1007/978-1-60761-744-0_13.
Alzheimer's disease (AD) is the most common neurodegenerative disease and cause of dementia. Significant strides toward understanding and developing therapies for AD have been supported by the use of transgenic mouse models of AD. Over the last two decades, a number of mouse models have been created to recapitulate the major neuropathological hallmarks of the disease, namely amyloid plaques and neurofibrillary tangles. These mice recapitulate many, although not all, of the key features of AD, and have been widely used in AD research. At the present time, there are numerous types of transgenic mice available for the study of AD, many of which have been characterized to some extent in terms of neuronal, neuropathological, and/or behavioral abnormalities. This repository of transgenic mice offers a wealth of opportunity to investigate the cellular mechanisms underlying AD, and the choice of mouse model for research should be guided by the specific questions to be answered. We provide here some considerations for selecting a mouse model of AD best suited to particular lines of investigation.
阿尔茨海默病（AD）是最常见的神经退行性疾病及痴呆症病因。利用AD转基因小鼠模型推动了在理解和开发AD治疗方法方面取得的重大进展。在过去二十年中，已创建了许多小鼠模型来重现该疾病的主要神经病理学特征，即淀粉样斑块和神经原纤维缠结。这些小鼠重现了AD的许多（尽管不是全部）关键特征，并已广泛应用于AD研究。目前，有多种类型的转基因小鼠可用于AD研究，其中许多已在神经元、神经病理学和/或行为异常方面得到了一定程度的表征。这个转基因小鼠库为研究AD潜在的细胞机制提供了丰富的机会，研究中对小鼠模型的选择应根据要回答的具体问题来指导。我们在此提供一些关于选择最适合特定研究方向的AD小鼠模型的考虑因素。
