Kucerová L, Fabian E, Fabianová J
Acta Univ Carol Med Monogr. 1977(78 Pt 2):71-4.
In a study of the aetiopathogenesis of primary hyperlipoproteinaemias, which has not yet been elucidated, we paid attention to the heparin-activated lipolytic enzymes. Lipoprotein lipase (LPL) and postheparin esterase (PHE) activity was determined in 35 patients with primary hyperlipoproteinaemia (HLP) type IV (average age 50 years), 28 with type V (average age 48 years) and 2 with type III (57 and 62 years). Since PHE activity is correlated to sex and in women also to age, these factors had to be taken into account. The average activity values for the given enzymes in the patients group did not differ from the results in the control group. From these enzymes activities we tried to analyse the findings in individual cases in which the values were lower or higher than the control group range. The low PHE activity in some patients with type IV and V was evidently secondary and due to hepatobiliary disorder (most frequently liver steatosis). The simultaneous elevation of LPL and PHE activity in type IV and V patients with a high serum lipoprotein concentration shows that the response of patients with extreme HLP to heparin is more pronounced. The low PHE activity in type III (tested in only 2 patients) could possibly indicate the liver disorder on which this metabolic disease may be based.
在一项尚未阐明的原发性高脂蛋白血症病因发病机制的研究中，我们关注了肝素激活的脂解酶。对35例IV型原发性高脂蛋白血症（HLP）患者（平均年龄50岁）、28例V型患者（平均年龄48岁）和2例III型患者（57岁和62岁）测定了脂蛋白脂肪酶（LPL）和肝素后酯酶（PHE）活性。由于PHE活性与性别相关，在女性中还与年龄相关，因此必须考虑这些因素。患者组中上述酶的平均活性值与对照组结果无差异。我们试图根据这些酶的活性分析个别病例中其值低于或高于对照组范围的结果。IV型和V型部分患者PHE活性低显然是继发性的，且归因于肝胆疾病（最常见的是肝脂肪变性）。IV型和V型血清脂蛋白浓度高的患者中LPL和PHE活性同时升高，表明极端HLP患者对肝素的反应更明显。III型患者（仅检测了2例）PHE活性低可能表明这种代谢疾病可能基于的肝脏疾病。
