Takeuchi Koji, Satoh Hiroshi
Kyoto Pharmaceutical University, Kyoto, Japan.
Curr Protoc Toxicol. 2010 Aug;Chapter 21:Unit 21.7. doi: 10.1002/0471140856.tx2107s45.
Many animal models have been devised for investigating the pathogenesis of intestinal lesions and for screening drugs for the treatment of intestinal ulcers in humans. Recently, particular attention has been focused on NSAID-induced intestinal lesions as a result of the development of the capsule endoscope and double-balloon endoscope. Ischemic enteritis, one of the most dramatic abdominal emergencies, is known to cause severe damage to the small intestine by a significant decrease of arterial blood flow in the small intestine. In this unit, two animal models for small intestinal damage induced by NSAIDs or intestinal ischemia are described. Also included are methods for lesion induction and evaluation of the damage as well as the measurement of pathogenic functional and biochemical changes.
为了研究肠道病变的发病机制以及筛选治疗人类肠道溃疡的药物，人们设计了许多动物模型。最近，由于胶囊内窥镜和双气囊内窥镜的发展，非甾体抗炎药（NSAID）引起的肠道病变受到了特别关注。缺血性肠炎是最严重的腹部急症之一，已知它会因小肠动脉血流量显著减少而对小肠造成严重损害。在本单元中，将描述两种由NSAIDs或肠道缺血引起的小肠损伤动物模型。还包括损伤诱导和损伤评估的方法，以及对致病性功能和生化变化的测量。
