Gaĭnutdinov M Kh, Konov V V, Ishmukhamedov R N, Zakharova T N, Khalilova M A, Mamatova Z A, Asrarov M I, Mirmakhmudova S I
Biokhimiia. 1990 Dec;55(12):2239-46.
In vivo thyroid hormones control the binding to mitochondria of low molecular weight water-soluble cytoplasmic mediators that are capable to induce oxidative phosphorylation uncoupling, by increasing the sensitivity of mitochondria to the effects of these mediators. In hyperthyroid rat liver mitochondria cytoplasmic mediators stimulate the phosphate-dependent transport of K+ and H+ in a greater degree than in liver mitochondria of control rats. The increase in the oxidative phosphorylation uncoupling by cytoplasmic mediators is one of mechanisms of thermogenesis stimulation by thyroid hormones.
在体内，甲状腺激素通过增加线粒体对低分子量水溶性细胞质介质作用的敏感性，来控制这些能够诱导氧化磷酸化解偶联的介质与线粒体的结合。在甲状腺功能亢进大鼠的肝线粒体中，细胞质介质对K⁺和H⁺的磷酸盐依赖性转运的刺激程度大于对照大鼠肝线粒体。细胞质介质导致的氧化磷酸化解偶联增加是甲状腺激素刺激产热的机制之一。
