Shyng Y C, Chi C Y, Devlin H, Sloan P
Department of Medical Research and Animal Study, Kaohsiung Military General Hospital, Kaohsiung, Taiwan 823, Republic of China.
Growth Factors. 2010 Dec;28(6):447-51. doi: 10.3109/08977194.2010.527966. Epub 2010 Oct 25.
Cartilage does not form in the tooth extraction socket of the normal rat. The aim of the study was to determine if adding BMP-6 to the extraction socket would cause chondrogenic differentiation in the diabetic rat. A group of 8-week-old rats were injected intraperitoneally with a diabetogenic agent, streptozotocin, and a control group received citrate buffer only. Three weeks later, the maxillary molar teeth were extracted and either BMP-6 or saline applied to the extraction sockets. Rats from each group were killed on days 3, 5, 7, and 9 after tooth extraction. In the diabetic rats treated with BMP-6, there was a cellular subperiosteal reaction at day 3 in the extra-alveolar tissues, which by day 7 had formed a large mass of cartilage. Cartilage was induced in the subperiosteal region of the socket extra-alveolar bone following the application of BMP-6 in the diabetic rat.
正常大鼠的拔牙创不会形成软骨。本研究的目的是确定向拔牙创添加骨形态发生蛋白-6（BMP-6）是否会在糖尿病大鼠中引起软骨形成分化。一组8周龄大鼠腹腔注射致糖尿病药物链脲佐菌素，对照组仅接受柠檬酸盐缓冲液。三周后，拔除上颌磨牙，并将BMP-6或生理盐水应用于拔牙创。每组大鼠在拔牙后第3、5、7和9天处死。在用BMP-6治疗的糖尿病大鼠中，拔牙后第3天在牙槽外组织出现细胞性骨膜下反应，到第7天已形成大量软骨。在糖尿病大鼠拔牙创牙槽外骨的骨膜下区域，应用BMP-6后诱导形成了软骨。
