Pillinger Michael H, Goldfarb David S, Keenan Robert T
New York University School of Medicine, NYU Hospital for Joint Diseases, New York, NY 10003, USA.
Bull NYU Hosp Jt Dis. 2010;68(3):199-203.
Gout is a chronic disease in which excessively high levels of serum urate (hyperuricemia) result in tissue depositions of sodium urate crystals and intermittent inflammatory attacks. Patients who have gout frequently experience a range of comorbidities, which complicates management and affects long-term prognosis. We review some of the more important of these comorbidities and consider the extent to which gout or hyperuricemia may be either a consequence or a cause of these related conditions. In addition, we briefly consider several neurological conditions in which the presence of gout or a high serum urate level may be associated with less disease, rather than more.
痛风是一种慢性疾病，血清尿酸水平过高（高尿酸血症）会导致尿酸钠晶体在组织中沉积，并引发间歇性炎症发作。痛风患者经常会出现一系列合并症，这使得治疗变得复杂，并影响长期预后。我们回顾其中一些较为重要的合并症，并探讨痛风或高尿酸血症在多大程度上可能是这些相关疾病的结果或原因。此外，我们简要考虑几种神经系统疾病，在这些疾病中，痛风或高血清尿酸水平的存在可能与疾病较少而非较多相关。
