Department of Psychology, Clemson University, Clemson, SC 29634, USA.
Brain Res. 2011 Jan 7;1367:207-12. doi: 10.1016/j.brainres.2010.10.040. Epub 2010 Oct 20.
An early study reported that, unlike sham-operated rats, rats made anosmic by olfactory bulbectomy (OBX) failed to compensate for the dilution of their diet with nonnutritive bulk by increasing their food intake. In the present study, the effects of a glucoprivic challenge, intraperitoneal-administered 350 mg/kg 2-deoxy-D-glucose (2-DG), on food intake were measured in OBX and sham-operated female rats. Sham-operated rats significantly increased their food intake, but in two separate experiments OBX rats displayed no increase in food intake during the first 2 h following administration. Blood glucose levels were nearly identical in both groups. Body weights and daily food intakes of OBX rats did not differ from the sham-operated controls throughout the studies. Bulbectomized rats also displayed a normal drinking response after an intraperitoneal injection of 1M hypertonic saline. Hypothalamic nuclei and the neural pathways mediating taste have been implicated in the feeding response to 2-DG. The present results suggest that olfactory input and olfactory neural pathways also mediate, at least in part, the feeding response to a glucoprivic challenge induced by intraperitoneal injection of 2-DG.
一项早期研究报告称，与假手术大鼠不同，嗅球切除术（OBX）致嗅觉缺失的大鼠不能通过增加食物摄入量来补偿饮食的非营养性稀释。在本研究中，测量了腹腔内给予 350mg/kg 2-脱氧-D-葡萄糖（2-DG）对 OBX 和假手术雌性大鼠食物摄入量的影响。假手术大鼠的食物摄入量显著增加，但在两项单独的实验中，OBX 大鼠在给药后 2 小时内食物摄入量没有增加。两组的血糖水平几乎相同。整个研究过程中，OBX 大鼠的体重和每日食物摄入量与假手术对照组无差异。腹腔内注射 1M 高渗盐水后，嗅球切除术大鼠也表现出正常的饮水反应。下丘脑核和介导味觉的神经通路已被牵涉到对 2-DG 的摄食反应中。本研究结果表明，嗅觉输入和嗅觉神经通路至少部分介导了腹腔内注射 2-DG 引起的糖剥夺挑战的摄食反应。
