Semin Cell Dev Biol. 2010 Dec;21(9):917-21. doi: 10.1016/j.semcdb.2010.10.006. Epub 2010 Oct 21.
The Epidermal Growth Factor family of peptide hormones and their four ERBB receptors are important in development of epithelia, the nervous system, and the cardiovascular system, and they continue to maintain these systems in adults. These growth factors and receptors are important drivers in human cancers, and they are the targets for several effective anti-cancer therapies in clinical use. The biology and pathogenesis of this system, and its importance for fundamental research in cancer biology is reviewed.
表皮生长因子家族的肽类激素及其四个 ERBB 受体在上皮组织、神经系统和心血管系统的发育中起着重要作用，并在成人中维持这些系统。这些生长因子和受体是人类癌症的重要驱动因素，也是几种临床应用的有效抗癌疗法的靶点。本文综述了该系统的生物学和发病机制及其在癌症生物学基础研究中的重要性。
